Sci Rep:长期阿司匹林治疗对阴茎勃起功能没有影响

2019-06-05 AlexYang MedSci原创

由于广谱的药理学作用,阿司匹林自从其合成之后成为了最为广泛使用的药物之一;然而,阿司匹林与阴茎勃起功能之间的相关性仍旧存在争议。最近,有研究人员探索了是否长期的阿司匹林药物治疗可以恶化或者保留勃起功能。研究发现,与成年对照小鼠相比,老龄化对照组小鼠中ICP、AUC和ICP/MAP比例均显著减少,并且这些影响伴随着eNOS蛋白表达的减少和更低的NO和cGMP水平。然而,nNOS蛋白的表达没有发现差异

由于广谱的药理学作用,阿司匹林自从其合成之后成为了最为广泛使用的药物之一;然而,阿司匹林与阴茎勃起功能之间的相关性仍旧存在争议。

最近,有研究人员探索了是否长期的阿司匹林药物治疗可以恶化或者保留勃起功能。研究发现,与成年对照小鼠相比,老龄化对照组小鼠中ICP、AUC和ICP/MAP比例均显著减少,并且这些影响伴随着eNOS蛋白表达的减少和更低的NO和cGMP水平。然而,nNOS蛋白的表达没有发现差异。对成年小鼠组,阿司匹林能够显著的抑制6-keto PGF1a、PGE2和TXB2的产生,而不能改变ICP、AUC和ICP/MAP比例或者改变eNOS、nNOS、COX-1和COX-2的表达。同时,阿司匹林也并不影响总的NO、cAMP或者cGMP浓度。研究人员在老龄化的小鼠组中也观察到了上述情况,即阿司匹林并不影响勃起功能。

最后,研究人员指出,他们的数据表明了长期的阿司匹林治疗并不加强或者减弱勃起功能。因此,它对勃起功能没有影响。

原始出处:


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    2019-09-27 habb
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    2019-06-07 dingxiaobo
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    2019-06-06 1ddf0692m34(暂无匿称)

    学习了,长知识

    0

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    2019-06-06 txqjm

    谢谢了,学习

    0

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