NAT MED:为什么女性预防艾滋病屡屡失败,新研究找到其“根源”

2018-03-03 佚名 Medicalxpress

为什么有些妇女会感染艾滋病毒,即使她们使用替诺福韦凝胶来预防?

为什么有些妇女会感染艾滋病毒,即使她们使用替诺福韦凝胶来预防

本周发表在《自然医学》上的南非艾滋病研究中心(CAPRISA)科学家的一项新研究表明,生殖器炎症大大降低了替诺福韦凝胶在预防妇女感染艾滋病毒方面的有效性。这些发现表明,需要解决生殖器炎症和粘附问题,以提高局部暴露前预防战略在妇女中预防艾滋病毒的有效性。

研究人员测量了阴道中的小蛋白质,称为细胞因子。阴道中细胞因子水平的升高表明即使在没有临床症状的情况下也存在炎症免疫反应。本研究以2.5岁以上的774名女性为研究对象,对生殖器炎症的标志物,HIV感染率和细胞因子水平进行了纵向研究。

来自马尼托巴大学医学微生物学研究人员和夸祖鲁纳塔尔大学的研究人员们发现,生殖器发炎的女性随后感染艾滋病毒的风险比没有炎症的女性高。

研究人员说:“减少女性生殖道的炎症可能会加强女性的艾滋病预防。”这项研究强调了生殖器炎症在艾滋病毒风险和改变艾滋病毒预防战略效力方面的主要作用。目前和未来提高局部PrEP疗效的尝试将受益于了解炎症的原因,以及开发治疗生殖器炎症的新策略。

尼托巴大学目前正在进行这样的努力,研究人员们正在进行一项研究,该研究使用抗炎的乙酰水杨酸(俗称阿司匹林)来减少女性生殖道的炎症反应。

与此同时,研究表明,替诺福韦凝胶为没有阴道炎症的妇女提供了57%的艾滋病毒感染保护,即使她们一贯使用这种凝胶也只能达到这个数字。

“这项研究为我们提供了一个重要的线索,以加强妇女的艾滋病毒预防。不仅是与遵守有关的行为有关,而且阴道中的生物过程也需要得到解决,以预防艾滋病毒,提高局部PREP的有效性。”

原始出处:
Lyle R McKinnon, Lenine J Liebenberg, Nonhlanhla Yende-Zuma, et al.Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.Nature Medicine.doi:10.1038/nm.4506.26 February 2018

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    2018-04-15 jyzxjiangqin

    女性预防艾滋病.

    0

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    2018-12-06 liye789132251
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    2018-04-02 jyzxjiangqin

    女性艾滋病的治疗

    0

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    2018-03-19 jyzxjiangqin

    积极预防艾滋病.

    0

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    2018-03-06 jyzxjiangqin

    女性预防艾滋病的重要性.

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    2018-03-03 Ellen1826810771

    学习了

    0

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