J Clincal Gastroenterology: 炎症性肠病患者患脑膜炎的风险更高

2021-07-28 MedSci原创 MedSci原创

炎症性肠病 (IBD) 患者通常是指克罗恩病 (CD) 和溃疡性结肠炎 (UC) 患者,患有这两种疾病的患者均处于感染风险明显增加的处境。

      炎症性肠病 (IBD) 患者通常是指克罗恩病 (CD) 和溃疡性结肠炎 (UC) 患者,患有这两种疾病的患者均处于感染风险明显增加的处境。在 IBD 患者中已经证实感染性疾病比如软组织感染,泌尿外科感染、妇科感染感染和肺炎的风险都明显增加。细菌性脑膜炎是一种罕见的但是非常严重的感染,肺炎链球菌是导致脑膜感染的主要原因。目前关于 IBD患者出现脑膜炎发病率的数据还十分有限。因此,本项研究旨在确定IBD 患者脑膜炎的发病率和危险因素。

 

      本项研究是一项回顾性队列和嵌套病例对照研究。研究人员将 IBD 患者与未患 IBD 的患者在年龄、性别、入组和地区方面进行了匹配。脑膜炎根据实验室和临床进行诊断。脑膜炎风险通过发病率比率计算。在 IBD 患者的嵌套病例对照研究中,脑膜炎的预测因子是用多变量条件逻辑回归模型确定的。

 

      本项研究最后确定了 50029 名克罗恩病 (CD) 患者和 59830 名溃疡性结肠炎 (UC) 患者与 296801 名非 IBD 对照者相匹配。有 85 名 CD 患者、77 名 UC 患者和 235 名对照者患有脑膜炎。与非IBD患者相比,CD患者患有脑膜炎的几率高2.17倍,UC患者有患脑膜炎的几率高1.63倍。在对 IBD 患者的相关协变量进行调整后,美沙拉嗪治疗与脑膜炎索赔的几率显着降低相关(OR:0.40,95%CI:0.26-0.62)。而至少有一种合并症与显着更高的脑膜炎几率有关(HR:2.21,95%CI:1.76-2.77)。

图:脑膜炎危险因素分析

      本项研究证实尽管脑膜炎的总体发病率较低,但与非 IBD 对照者相比,IBD 患者的风险增加。合并症是IBD 患者脑膜炎的危险因素。

 

 

原始出处:

Kochar. Et al. Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis. Journal of Clinical Gastroenterology.2021.

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    2021-12-25 许安
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createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Sep 19 04:04:32 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073397, encodeId=38e020e3397a7, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Dec 25 16:04:32 CST 2021, time=2021-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068299, encodeId=87711068299df, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547460, encodeId=d24a154e460d7, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600106, encodeId=8ae016001067f, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003666, encodeId=7066100366621, content=<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>患者患<a href='/topic/show?id=af3085053ca' target=_blank style='color:#2F92EE;'>#脑膜炎#</a>风险高,原因??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病), TopicDto(id=85053, encryptionId=af3085053ca, topicName=脑膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Thu Jul 29 20:44:52 CST 2021, time=2021-07-29, status=1, ipAttribution=)]
    2021-11-08 1482963am12暂无昵称

    学习了

    0

  5. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547460, encodeId=d24a154e460d7, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600106, encodeId=8ae016001067f, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003666, encodeId=7066100366621, content=<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>患者患<a href='/topic/show?id=af3085053ca' target=_blank style='color:#2F92EE;'>#脑膜炎#</a>风险高,原因??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病), TopicDto(id=85053, encryptionId=af3085053ca, topicName=脑膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Thu Jul 29 20:44:52 CST 2021, time=2021-07-29, status=1, ipAttribution=)]
    2021-11-03 1482963am12暂无昵称

    非常值得学习的内容

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2065403, encodeId=16012065403d5, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu May 12 02:04:32 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712874, encodeId=9bb41e1287407, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547460, encodeId=d24a154e460d7, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600106, encodeId=8ae016001067f, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003666, encodeId=7066100366621, content=<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>患者患<a href='/topic/show?id=af3085053ca' target=_blank style='color:#2F92EE;'>#脑膜炎#</a>风险高,原因??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病), TopicDto(id=85053, encryptionId=af3085053ca, topicName=脑膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Thu Jul 29 20:44:52 CST 2021, time=2021-07-29, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2065403, encodeId=16012065403d5, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu May 12 02:04:32 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712874, encodeId=9bb41e1287407, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547460, encodeId=d24a154e460d7, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600106, encodeId=8ae016001067f, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Fri Jul 30 02:04:32 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003666, encodeId=7066100366621, content=<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>患者患<a href='/topic/show?id=af3085053ca' target=_blank style='color:#2F92EE;'>#脑膜炎#</a>风险高,原因??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病), TopicDto(id=85053, encryptionId=af3085053ca, 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  8. 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    2021-07-29 小小医者

    #炎症性肠病#患者患#脑膜炎#风险高,原因??

    0

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