SCI REP:肺气肿是非小细胞肺癌患者肺癌放射治疗后发生放射性肺炎的危险因素!

2017-06-05 xing.T MedSci原创

该研究的结果表明,肺气肿是明确接受TRT治疗后局部晚期NSCLC患者的高危因素,尤其是鳞状细胞癌患者。

在局部晚期非小细胞肺癌NSCLC)患者中,肺气肿已被证实是一种具有较高患病率的疾病。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员共招募了153例局部晚期非小细胞肺癌患者,旨在评估明确的胸部放射治疗(TRT)后放射性肺炎与肺气肿之间存在的相关性。

研究人员发现2级、3级和5级的放射性肺炎的发生率分别为11.1%、9.8%和0.7%。单因素分析显示年龄、肺气肿、用力肺活量(FVC)、动脉血氧分压(PO2)和平均肺脏剂量(MLD)与鳞状细胞癌患者2级以上或3级以上放射性肺炎的风险显著相关(P<0.05)。

Logistic回归分析表明,肺气肿是鳞状细胞癌患者发生放射性肺炎的独立危险因素(P<0.05)。接受者操作特征(ROC)分析显示将年龄、肺气肿、FVC、PO2和MLD进行合并,对鳞状细胞癌患者发生放射性肺炎有较高的预测价值(2级以上放射性肺炎AUC为0.856,3级以上放射性肺炎AUC为0.882)。Kaplan Meier分析发现,肺气肿越严重,鳞状细胞癌患者放射性肺炎的发生率越高。

该研究的结果表明,肺气肿是明确接受TRT治疗后局部晚期NSCLC患者的高危因素,尤其是鳞状细胞癌患者。

原始出处:


Ziyang Zhou,et al. Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-02739-4

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    2017-06-10 sam2000jie

    学习了

    0

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  5. 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    2017-06-07 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Jun 06 10:35:55 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-07 大爰

    学习并分享!!!

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Jun 06 10:35:55 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 131****2916

    不错的文章,可以考虑

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Jun 06 10:35:55 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 1dea4a7em68(暂无匿称)

    这观点很新鲜

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Jun 06 10:35:55 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 Y—xianghai

    学习了新知识

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Jun 06 10:35:55 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 明天会更好!

    学习了,值得分享!

    0

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p53信号通路可能在吸烟者的肺气肿发病机制中扮演重要角色。目前已知,p53在密码子72的多态性可以影响凋亡效应蛋白,并且小鼠双微小体2同源物(MDM2)SNP309的多态性可以增加MDM2的表达。近期,一项发表在杂志Plos One上的研究旨在评估吸烟者中的p53和MDM2的基因多态性,并评估这些基因中的SNPs在肺气肿发病机制中的作用。此项研究共纳入了365例吸烟患者,并确定了p53和MDM2基

NEJM:支气管内瓣膜治疗可显著改善无叶间侧支通气的肺气肿

通过使用单向瓣膜植入的经支气管镜肺减容术是重度肺气肿患者的潜在治疗方法。迄今为止,好处一直不大,但都被假设效果在叶间侧支通气患者中比那些有侧支通气的患者大的多。

盘点:近期有关肺气肿相关研究进展

肺气肿是指终末细支气管远端的气道弹性减退,过度膨胀、充气和肺容积增大或同时伴有气道壁破坏的病理状态。阻塞性肺气肿的发病机制尚未完全清楚。一般认为与支气管阻塞以及蛋白酶-抗蛋白酶失衡有关。本文梅斯医学小编就近期有关肺气肿相关研究汇总,与大家分享学习。【1】JAMA:肺气肿的治疗:支气管内线圈治疗 vs 标准治疗(RENEW)初步的临床试验表明,对肺气肿和严重肺过度充气患者,使用支气管内线圈压缩肺

Lancet:肺气肿后严重的α1抗胰蛋白酶缺乏患者应考虑强化治疗

背景:α1蛋白酶抑制剂(A1PI)强化治疗α1抗胰蛋白酶缺乏症的疗效尚未通过随机、安慰剂对照试验得到证实。和肺活量测定相比,CT-测量在α1抗胰蛋白酶缺乏肺气肿疾病进展的肺密度时灵敏度更大,因此,该研究的目的是应用此措施评估强化治疗的功效。方法:RAPID研究是一项A1PI治疗α1抗胰蛋白酶缺乏症患者的多中心,双盲,随机,平行组,安慰剂对照试验。研究人员在13个国家28个国际研究中心招募合格的非吸