JASN:透析患者的心脏骤停风险可能归因于遗传

2015-11-23 MedSci译 MedSci原创

与普通人群相比,透析患者的心脏骤停率是普通人群的20倍。研究人员考虑到透析患者发生心脏骤停是否与遗传因素有关。研究人员收集了647457例慢性透析的样本,并从中确定了5117对来自同一个家庭的患者。这些患者每一个都有来自相同人群的匹配对照参与者。McNemar测试被用来比较的家族相关和不相关的匹配者对之间心脏骤停的危险。与表型匹配的无关对照相比,没有共同居住过的的基因相关的家庭成员心脏骤停比值比为

与普通人群相比,透析患者的心脏骤停率是普通人群的20倍。研究人员考虑到透析患者发生心脏骤停是否与遗传因素有关。

研究人员收集了647457例慢性透析的样本,并从中确定了5117对来自同一个家庭的患者。这些患者每一个都有来自相同人群的匹配对照参与者。McNemar测试被用来比较的家族相关和不相关的匹配者对之间心脏骤停的危险。

与表型匹配的无关对照相比,没有共同居住过的的基因相关的家庭成员心脏骤停比值比为1.88(95%置信区间[95%Cl],1.25〜2.84)。有血亲关系的家庭成员并且居住在同一个环境中比值比为1.66(95%Cl,1.20至2.28)。遗传无关的配偶,但共同生活在同一环境中,心脏骤停的比值比为0.95(95%Cl,0.60至1.59)。

透析患者的心脏骤停风险可能是由于遗传因素。还需要更多的研究来确定终末期肾病心血管疾病的危险的候选基因。

原始出处:

Kevin E. Chan,Christopher Newton-Cheh,James F. Gusella,et al.Heritability of Risk for Sudden Cardiac Arrest in ESRD,JASN,2015.11.23

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    2016-01-17 chenhongpeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1941269, encodeId=6f101941269d1, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Sun Jan 17 00:47:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44387, encodeId=63784438e45, content=请问怎么获得原文呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aabe1667714, createdName=尼土土, createdTime=Wed Dec 02 11:26:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570586, encodeId=447215e058696, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Wed Nov 25 09:47:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43606, encodeId=422c436064c, content=同问呀……, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Tue Nov 24 00:59:00 CST 2015, time=2015-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43602, encodeId=bbe943602e4, content=电解质等没有影响?, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Nov 23 22:45:00 CST 2015, time=2015-11-23, status=1, ipAttribution=)]
    2015-12-02 尼土土

    请问怎么获得原文呢

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1941269, encodeId=6f101941269d1, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Sun Jan 17 00:47:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44387, encodeId=63784438e45, content=请问怎么获得原文呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aabe1667714, createdName=尼土土, createdTime=Wed Dec 02 11:26:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570586, encodeId=447215e058696, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Wed Nov 25 09:47:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43606, encodeId=422c436064c, content=同问呀……, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Tue Nov 24 00:59:00 CST 2015, time=2015-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43602, encodeId=bbe943602e4, content=电解质等没有影响?, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Nov 23 22:45:00 CST 2015, time=2015-11-23, status=1, ipAttribution=)]
    2015-11-24 dearluodi

    同问呀……

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1941269, encodeId=6f101941269d1, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Sun Jan 17 00:47:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44387, encodeId=63784438e45, content=请问怎么获得原文呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aabe1667714, createdName=尼土土, createdTime=Wed Dec 02 11:26:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570586, encodeId=447215e058696, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Wed Nov 25 09:47:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43606, encodeId=422c436064c, content=同问呀……, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Tue Nov 24 00:59:00 CST 2015, time=2015-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43602, encodeId=bbe943602e4, content=电解质等没有影响?, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Nov 23 22:45:00 CST 2015, time=2015-11-23, status=1, ipAttribution=)]
    2015-11-23 lovetcm

    电解质等没有影响?

    0

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