JAHA:艾滋病病毒感染者植入心脏复律除颤器的发生率、预测因素和效应

2018-09-05 xing.T MedSci原创

由此可见,与未感染的对照者相比,PHIV的ICD出院率更高。在PHIV中,可卡因使用和纽约心功能分级与ICD出院增加相关,并且ICD出院与随后的心力衰竭和心血管死亡增加相关。

感染艾滋病毒的个人(PHIV)发生心脏猝死的风险增加,植入式心律转复除颤器(ICD)可预防心源性猝死(SCD)。目前,尚未有关于PHIV中接受ICD治疗的发生率、预测因素和效应的数据。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员比较了59例PHIV和267例未感染对照者接受ICD后的出院率。对于PHIV,研究人员评估了传统血管危险因素与HIV特异性参数与ICD出院之间的关系,然后检验了PHIV中ICD出院是否与心血管死亡率或心力衰竭入院相关。

植入ICD的指证在各组间相似。与对照组相比,植入ICD的PHIV更可能患有冠状动脉疾病并使用可卡因。在随访中,PHIV的ICD出院率较高(39% vs. 20%; P=0.001;中位随访期为19个月)。在PHIV中,使用可卡因、冠状动脉疾病、QRS持续时间和更高的纽约心功能分级与ICD出院相关。ICD出院具有预后效应,随后心力衰竭入院发生率增加1.7倍,心血管死亡发生率增加2倍,这种效应在种族/民族和性别亚组中保持一致。

由此可见,与未感染的对照者相比,PHIV的ICD出院率更高。在PHIV中,可卡因使用和纽约心功能分级与ICD出院增加相关,并且ICD出院与随后的心力衰竭和心血管死亡增加相关。

原始出处:

Raza M.et al. Incidence, Predictors, and Outcomes of Implantable Cardioverter‐Defibrillator Discharge Among People Living With HIV.JAHA.2018. https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009857

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    2018-09-09 苏小雨

    学习啦厉害厉害

    0

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    2018-09-07 zhaohui6731
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    2018-09-07 zhouqu_8
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    2018-09-07 jiyangfei
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