Theranostics:细胞外膜泡在心血管疾病诊断与治疗中的作用

2017-12-14 Johnny “外泌体之家”微信号

细胞外囊泡(EV)是具有脂质双层膜的小囊泡,可以由大多数细胞类型释放,并在大多数体液中检测到。EV通过将其生物活性成分转移到受体细胞或激活靶细胞中的信号传导途径来发挥细胞间通讯的关键功能。越来越多的证据表明EV在心血管疾病(CVDs)中的重要调节作用。由心肌细胞、内皮细胞、成纤维细胞和干细胞分泌的EV在心脏肥大、心肌细胞存活和凋亡、心脏纤维化以及与CVD有关的血管生成等病理生理过程中起重要作用。

细胞外囊泡(EV)是具有脂质双层膜的小囊泡,可以由大多数细胞类型释放,并在大多数体液中检测到。EV通过将其生物活性成分转移到受体细胞或激活靶细胞中的信号传导途径来发挥细胞间通讯的关键功能。越来越多的证据表明EV在心血管疾病(CVDs)中的重要调节作用。由心肌细胞、内皮细胞、成纤维细胞和干细胞分泌的EV在心脏肥大、心肌细胞存活和凋亡、心脏纤维化以及与CVD有关的血管生成等病理生理过程中起重要作用。

上海大学肖杰教授发表了一篇关于EV在心血管疾病诊断与治疗中的作用的综述。在这篇综述中,研究者首先概述目前关于EV的物理特性、生物成分和分离方法的知识。然后,重点介绍心血管EV的功能作用及其在心血管疾病中的病理生理效应,以及总结EV作为心血管疾病治疗剂和生物标志物的潜力。最后,讨论EV的具体应用,作为一种新型的药物输送系统和EV在再生医学领域的应用。

原始出处:

Bei Y,et al.,Extracellular Vesicles in Cardiovascular Theranostics.Theranostics. 2017 Sep 26;7(17):4168-4182.

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    2018-01-29 海豹
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