JCC: 阑尾切除术对于治疗难治性溃疡性结肠炎的疗效分析

2019-02-09 MedSci MedSci原创

阑尾易于发炎,切除阑尾是否可以减少溃疡性结肠炎的发生目前还没有定论。本研究的目的是检验阑尾切除术对治疗难治性溃疡性结肠炎[UC]患者病程的调节作用。

背景和目的
阑尾易于发炎,切除阑尾是否可以减少溃疡性结肠炎的发生目前还没有定论。本研究的目的是检验阑尾切除术对治疗难治性溃疡性结肠炎[UC]患者病程的调节作用。

方法
本项研究纳入的患者为治疗难治性UC且需行直肠结肠切除术的患者,首先接受腹腔镜阑尾切除术。主要终点是3个月和12个月后的临床反应。次要终点是内镜缓解,病理反应。根据Geboes评分对阑尾标本以及术前和术后活组织检查进行组织学分级。

结果
本项研究共有30名患者[53%男性],中位年龄40岁进行了阑尾切除术,术前中位总Mayo评分为9 [IQR,8-11]。12个月后,9名患者[30%]有持续的临床反应,其中5 [17%]患者在内镜下缓解。28例患者可进行病理学评估。中位数为13.0周[范围7-51]后,13例患者[46%]出现组织学复发,与无炎症或广泛溃疡相比,阑尾高度炎症可预测溃结的复发[85%vs 20%,p = 0.001]。

结论
阑尾切除术在三分之一的治疗难治性UC患者中有效,相当一部分患者在1年后显示完全内镜缓解。几乎50%的患者出现组织学复发,并且与阑尾活动性炎症,疾病持续时间较短有关。

原始出处:

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    2020-01-09 nymo
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    2019-02-11 freve
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    2019-02-10 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2019-02-09 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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