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科伦药业LAG3单抗KL-A289获得CDE临床受理

2020-05-23 医药魔方Info 医药魔方Info

LAG3单抗
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5月22日，科伦药业提交的1类新药LAG3单抗KL-A289注射液临床申请获得CDE受理。

5月22日，科伦药业提交的1类新药LAG3单抗KL-A289注射液临床申请获得CDE受理。

LAG3（lymphocyte activation gene 3，LAG3，CD223）是一种免疫检查点受体蛋白，主要表达在活化的T细胞、NK细胞、B细胞和浆细胞树突细胞。LAG3可通过和MHC II分子的结合，下调T细胞的活性。同时，LAG3也可增强调节性T细胞（Treg）的抑制活性。利用治疗性抗体抑制LAG3，可解除对T细胞的抑制，增强机体免疫应答。

据统计，目前全球共有31款涉及LAG3靶点的在研项目。除eftilagimod alpha（LAG3-Fc融合蛋白）和AVA-017（LAG3拮抗剂）外，均为治疗性抗体。从研发进展来看，已有7款产品处于临床II期，9款处于临床I期。国内开发该靶点的企业有信达生物、维立志博和恒瑞医药等。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2083828, encodeId=b7c820838283d, content=<a href='/topic/show?id=b822e481524' target=_blank style='color:#2F92EE;'>#科伦药业#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74815, encryptionId=b822e481524, topicName=科伦药业)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Mon Sep 21 15:34:13 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600237, encodeId=c82360023edc, content=未来应该是联用，与PD-1联用, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:45 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600236, encodeId=ffc56002361f, content=哪个瘤种？, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:19 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2020-09-21 yese

    #科伦药业#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2083828, encodeId=b7c820838283d, content=<a href='/topic/show?id=b822e481524' target=_blank style='color:#2F92EE;'>#科伦药业#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74815, encryptionId=b822e481524, topicName=科伦药业)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Mon Sep 21 15:34:13 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600237, encodeId=c82360023edc, content=未来应该是联用，与PD-1联用, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:45 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600236, encodeId=ffc56002361f, content=哪个瘤种？, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:19 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2020-05-23 lovetcm

    未来应该是联用，与PD-1联用

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2083828, encodeId=b7c820838283d, content=<a href='/topic/show?id=b822e481524' target=_blank style='color:#2F92EE;'>#科伦药业#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74815, encryptionId=b822e481524, topicName=科伦药业)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Mon Sep 21 15:34:13 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600237, encodeId=c82360023edc, content=未来应该是联用，与PD-1联用, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:45 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600236, encodeId=ffc56002361f, content=哪个瘤种？, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat May 23 11:43:19 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2020-05-23 lovetcm

    哪个瘤种？

    0