Lancet HIV:HIV感染人群肿瘤、心肌梗塞、终末期肝病及肾病风险因素研究

2019-01-23 zhangfan MedSci原创

研究认为,HIV感染人群非HIV相关肿瘤、心肌梗塞、终末期肝病及肾病的主要风险因素与一般人群相同,对相应风险因素采取必要的干预措施有助于降低HIV感染人群的并发症风险

HIV感染者其非HIV相关肿瘤、心肌梗塞、终末期肝病和肾病的负担增加,近日研究人员就HIV感染者的特异性风险因素进行了考察。

研究人员考察了2000-14年间,美国及加拿大相关HIV感染者资料,肿瘤、心肌梗塞、终末期肝病和肾病的传统危险因素包括吸烟、高血压、总胆固醇升高、II型糖尿病、肾损伤 (4期慢性肾病)、丙型肝炎病毒和乙型肝炎病毒感染。与艾滋病相关的危险因素是CD4计数低(每μ1<200个细胞)、可检测的血浆HIV RNA(>400个拷贝/ml)和临床艾滋病诊断史。

参与研究的HIV感染人群中,非HIV相关肿瘤、心肌梗塞、终末期肝病以及终末期肾病的患者分别有1405例、345例、387例以及255例,HIV男性感染者占80%。研究发现,戒烟可降低24%的肿瘤风险以及37%的心肌梗塞风险。降低总胆固醇和保持健康的对降低心肌梗死风险的贡献分别为44%和42%;HCV感染导致了33%的终末期肝病;高血压、高胆固醇、血浆HIV RNA以及低CD4细胞计数对终末期肾病的贡献分别为39%、22%、19%以及13%。

研究认为,HIV感染人群非HIV相关肿瘤、心肌梗塞、终末期肝病及肾病的主要风险因素与一般人群相同,对相应风险因素采取必要的干预措施有助于降低HIV感染人群的并发症风险。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-26 howi
  3. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-02 衣带渐宽

    学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-01 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

相关资讯

Science:揭示先天免疫系统介导的HIV纳米颗粒免疫原靶向生发中心机制

免疫系统能够识别纳米和微米大小的颗粒(比如病毒和细菌)并对它们作出反应。纳米颗粒经输入淋巴被运送到淋巴组织中,经内化和加工后用于树突细胞的抗原呈递,并且通过B细胞受体(BCR)的结合激活B细胞。免疫识别的这些特征促进人们将纳米颗粒抗原用于许可的疫苗中,比如HPV疫苗和乙肝病毒疫苗,并且在开发新疫苗时促进人们设计纳米颗粒形式的免疫原。对HIV病毒而言,来自临床前动物模型的证据表明相比于单体抗原,纳米

PNAS:中疾控合作团队发现同亚型不同簇HIV-1具不同免疫损伤力及其发生机理

中疾控邵一鸣团队早先报道过中国性传播艾滋病起源于泰国CRF01AE亚型的多个流行簇(C1-C8),引起当前艾滋病流行三大病毒簇包括,在异性人群传播的1簇(C1)和男同性恋(MSM)人群传播的4簇和5簇(C4、C5)。

JCO:HIV感染对肝癌预后的影响

肝细胞癌(HCC)是HIV患者死亡的主要原因,HIV血清阳性可能会影响肝细胞癌患者的预后。JCO近期发表了一篇文章,研究HIV是否影响HCC患者的总生存(OS)。

j nat prod:中国学者发现具有抗HIV活性的二萜化合物

暗罗属(学名:Polyalthia)是番荔枝科下的一个属,为乔木或灌木植物。近日,海南师范大学宋小平教授课题组报道从一种海南暗罗的根中分离得到了一些3,4-裂环-降碳的克罗烷型二萜化合物,并研究了它们的抗HIV活性。

NATURE:HIV如何避免先天免疫感知?

在哺乳动物中,RNA的2'-O-甲基化是一个重要的分子特征,通过该分子特征,细胞先天免疫系统得以区分内源性和外源性信使RNA。

谁会想到她们是这样感染了HIV

2016年12月30日,农历腊月初二,34名女性在某省城的ZC医院接受了同样的治疗。然而,谁也没有想到,这一场治疗会让34个家庭都没有过好接下来的鸡年春节。由于一个人的工作疏忽,5名女性感染了HIV,其中两人已有孕在身[1]。其余29人也经历了长达半年的随访,她们的生活过得并不平静。或许,这5名无辜的女性怎么也想不到艾滋病居然会离她们那么近。颇受争议的LIT将这34个家庭连在一起的,是一种叫做