Diabetes Obes metab:朱大龙教授和毕艳教授团队SPECIFY临床研究结果

2018-12-21 佚名 南京鼓楼医院内分泌科

南京鼓楼医院内分泌科朱大龙教授和毕艳教授团队的SPECIFY临床研究最近被Diabetes, Obesity and Metabolism杂志接收,影响因子5.98分。

南京鼓楼医院内分泌科朱大龙教授和毕艳教授团队的SPECIFY临床研究最近被Diabetes, Obesity and Metabolism杂志接收,影响因子5.98分。

2型糖尿病患者的用药决策需要临床医生平衡考虑降糖疗效、低血糖风险、对体重的影响等多方面的因素。目前针对二甲双胍单药治疗不达标的2型糖尿病患者,二联用药的选择仍需要来自中国人群的临床研究循证医学证据。由南京鼓楼医院内分泌科牵头联合全国11个中心共同完成了SPECICY研究,这是一项非盲、随机化、平行对照临床试验。研究旨在评估中国2型糖尿病患者在二甲双胍单药控制血糖失效基础上联用DPP-4抑制剂或磺脲类药物48周后的降糖疗效及安全性。该研究共纳入388例2型糖尿病患者,在二甲双胍单药控制血糖失效后,随机入组接受沙格列汀或格列美脲联合治疗,主要终点为:48周时糖化血红蛋白(HbA1c)<7.0%、无低血糖事件(血糖<3.9 mmol/L伴或不伴有症状)且无体重增加(体重增加<3.0%)的患者比例。

研究主要成果  

经过为期48周治疗,与格列美脲(平均剂量为2.5 mg/d)联合二甲双胍治疗相比,沙格列汀联合二甲双胍治疗组有更大比例的患者达到主要复合研究终点(43.3% vs. 31.3%)。治疗48周时,两个治疗组的HbA1c平均下降幅度相似;沙格列汀联合二甲双胍治疗患者的体重平均下降0.7 kg,相比之下,格列美脲联合二甲双胍治疗患者的体重增加0.9 kg。同时,与格列美脲联合二甲双胍治疗相比,沙格列汀联合二甲双胍治疗组发生低血糖的患者比例也明显下降(3.1% vs. 12.8%)。此外,亚组分析显示,与格列美脲组相比,基线HbA1c<8.0%、糖尿病病程<5年或体质指数≥25.0 kg/m2的患者接受沙格列汀治疗后达到主要复合终点的比例显著升高。

致谢

衷心感谢SPECIFY研究的各分中心单位:南京市第一医院,安徽医科大学第一附属医院,淮安市第一人民医院,无锡市人民医院,常州市第二人民医院,苏州大学附属第一医院,南京浦口区中心医院,南京军区南京总医院,东南大学附属中大医院,昆山市第一人民医院;感谢各位研究者和参与人员的支持和付出!

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    2019-11-27 guojianrong
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    2019-05-11 feather89
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    2018-12-28 hb2008ye
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    2019-03-22 一闲
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1638907, encodeId=43d3163890e56, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 05 11:27:00 CST 2019, time=2019-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739505, encodeId=0a351e395059f, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Fri Dec 28 06:27:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887970, encodeId=bf56188e970e7, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Nov 27 01:27:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727785, encodeId=fee51e277853f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat May 11 15:27:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760938, encodeId=31971e60938cc, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Fri Dec 28 20:27:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896435, encodeId=8224189643580, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Mar 22 12:27:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902189, encodeId=26021902189a1, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Wed May 22 20:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356060, encodeId=8b3c35606074, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Sat Dec 22 05:41:32 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356043, encodeId=d851356043f5, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Dec 21 22:51:47 CST 2018, time=2018-12-21, status=1, ipAttribution=)]
    2018-12-22 txqjm

    谢谢了,学习

    0

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    2018-12-21 惠映实验室

    学习了,谢谢分享。

    0

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患者, 女, G2P1, 33岁, 因“停经 35+1周,发现死胎、肝功能异 常1天”于2015年1月31日19时9分入院。LMP 2014年5月 27日,孕期未规律产检,胎儿 NT、唐氏筛查、排畸超声、 OGTT 等 均未查。仅于2015年 1 月 26 日孕 34+5周于当地医院行 I 级 B 超检查,结果提示:BPD 88mm, FLC 70mm,腹围363mm,胎儿脐动 脉测值正常范围,