JAMA Otolaryngol Head Neck Surg:心血管疾病与突发性感官听力损失相关性研究

2018-01-07 AlexYang MedSci原创

到耳蜗血管供给的中断一直以来被认为是突发性感官听力损失(SSNHL)的主要发病原因,并且一些心血管疾病(CCVD)的风险因素与SSNHL相关,包括重度抽烟、酒精消费和血栓的形成,SSNHL与CCVD之间的联系到目前为止还没有被彻底的阐明。最近,有研究人员进行了旨在评估SSNHL与CCVD之间关系的研究。研究为一个回顾性的倾向分值匹配群体研究,样本来自韩国国家健康安全服务机构。研究发现,770名病人

到耳蜗血管供给的中断一直以来被认为是突发性感官听力损失(SSNHL)的主要发病原因,并且一些心血管疾病(CCVD)的风险因素与SSNHL相关,包括重度抽烟、酒精消费和血栓的形成,SSNHL与CCVD之间的联系到目前为止还没有被彻底的阐明。最近,有研究人员进行了旨在评估SSNHL与CCVD之间关系的研究。研究为一个回顾性的倾向分值匹配群体研究,样本来自韩国国家健康安全服务机构。

研究发现,770名病人中,385(50%)名病人为女性,并且370(48.1%)名年龄在45到64岁之间。在研究群体中的为期11年的跟踪调查期间,66名病人发展为CCVD,比如中风和急性心肌梗塞,其中18名为SSNHL组的病人(发生率为1000人每年13.5个案例)和48名为比较组参与者(发生率1000人每年7.5个案例)。在调整了其他因素后,11年跟踪调查期间的CCVD风险比在病人中要比SSNHL高出2.18倍(95% CI,1.20-3.96)。另外,中风风险的增加与SSNHL相关(HR, 2.02; 95% CI, 1.16-3.51)。然而,SSNHL与心肌梗塞风险却没有联系(HR, 1.18; 95% CI, 0.25-5.50)。

最后,研究人员指出,他们的观察性的研究利用了国家数据库,并且阐释了SSNHL与CCVD风险的增加相关,尤其是中风。因此,对病人进行CCVD迹象的监控应该考虑到被诊断为患有SSNHL的病人中去。

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    2018-01-09 ysjykql
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    2018-01-07 hhh678

    henhao

    0

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最近,有研究人员在老年人中探究了双重和单独(视觉和听力)感官丧失与抑郁和焦虑症状之间的关系。研究包括了2890名年龄不小于60岁的老年人。主观视觉丧失、自我报道的听力损失或者双重感官丧失对抑郁和焦虑的影响通过贺普金斯症状检核表10来进行评估,并在时间基点和6年跟踪调查中利用了线性混合模型进行了分析。研究发现,听力损失与增加的抑郁(b = 0.1750, SE = 0.07, P = .02)和焦虑

Am J Public Health:中国听力损失老年人中助听器购置分析

最近,有研究人员调查了中国老年人助听器购置的流行度和相关的因素。研究人员从一个基于群体调查的关于耳朵和听力障碍的研究中获得了相关数据,这个研究是2014年到2015年在中国的4个省份进行的。专业调查人员进行了纯音听力测定,并且听力学家进一步确定了听力损失。研究人员依据听力条件和听力学家的建议,鉴定除了1503名参与者需要佩戴助听器。在1503名参与者中,评估的听力助听器流行度为6.5%(95% c

Mol Med Rep:二代测序在线粒体变异中的应用:听力损失病人中m.7511T>C的研究

粒体基因组(mtDNA)变异诱导的线粒体活性打断可以成为许多疾病的起因,其中包括了听力损失(HL)。其中一个与HL有关的线粒体变异为m.7511T>C,并且位于线粒体编码的tRNA丝氨酸(UCN)基因上。最近,有研究人员利用二代测序技术在母系遗传HL的2名病人中进行了全mtDNA测序,从而搜索HL变异,并且利用实时荧光定量PCR技术在患有HL的1644名病人中对m.7511T>C变异进

Sci Rep:ATP1A3突变能够引起进行性听觉神经病变

零星分散的、习语后的和进行性听觉神经病谱系障碍(ANSD)的病因学和流行度很少有文献报道。因此,最近,有研究人员对这些案例的流行度和分子病因学进行了评估。研究发现,106名零星进行性听力损失病人中的3名发展转变为明显的ANSD。通过全外显子组测序和随后的生物信息学分析,这3名病人中的2名具有共同的新的变异,即ATP1A3的p.E818K位点,该基因之前曾报道能够引起排斥性CAPOS(小脑性共济失调

BMC Med Genet: 全外显子测序鉴定到了一个能偶引起低频率听力损失的WFS1基因错义突变位点

低频率非综合症听力损失(LF-NSHL)是一种少见的和遗传性障碍。最近,有研究人员报道了在一个患有LF-NSHL家族中,在沃尔弗拉姆综合征1(WFS1)基因中发现的一个错义突变。研究人员对该家族成员进行了听觉测定和成像评估,包括了纯音听觉测定和颞骨计算机断层扫描。研究人员还对受影响和不受影响的2名参与者中搜集了血样。为了确定该家族听力损失的遗传背景,研究人员利用了全基因组外显子测序进行了遗传分析。