Int J Cardiol:主动脉瘤外科修复与降低的痴呆发生率

2018-12-08 xing.T MedSci原创

由此可见,与NST相比,OSR与降低主动脉瘤患者痴呆发生率有关。

痴呆和主动脉瘤共享临床危险因素和分子信号通路。然而,尚未有研究评估痴呆与主动脉瘤之间的关联。主动脉瘤开放手术修复(OSR)对未来痴呆事件的潜在影响尚不清楚。

近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员使用台湾国家健康保险研究数据库(NHIRD)进行了这项全国性的基于人群的回顾性队列研究。研究人员比较了下列人员中13年随访期间痴呆的累积发生率:1)主动脉瘤和非主动脉瘤患者;2)接受OSR、血管内动脉瘤修复(EVAR)或非手术治疗(NST)的主动脉瘤患者。

该研究纳入了19921例主动脉瘤患者和19921例匹配对照者。与对照者相比,主动脉瘤组痴呆的发生率显著增加(校正风险比(HR)=3.559,p<0.001)。此外,5409例主动脉瘤患者接受了外科手术治疗,而5409例匹配的主动脉瘤患者则没有接受手术治疗。接受OSR治疗的主动脉瘤患者痴呆发生率明显低于接受NST治疗的患者(调整后的HR=0.638,95%可信区间(CI)=0.411-0.764,p<0.001)。接受EVAR治疗的患者痴呆发生率低于接受NST治疗的患者。

由此可见,与NST相比,OSR与降低主动脉瘤患者痴呆发生率有关。

原始出处:


Jen-Chun Wang,et al.Surgical repair of aortic aneurysms and reduced incidence of dementia.International Journal of Cardiology.2018.https://doi.org/10.1016/j.ijcard.2018.11.137

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    2019-01-13 1243d5bbm27暂无昵称

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    2018-12-09 zwjnj2

    好好学习认真的学习

    0

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    2018-12-08 junJUN

    老年人痴呆何药可用??

    0

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