J Oral Microbiol:唾液中牙龈卟啉单胞菌的丰度与慢性和侵袭性牙周炎密切有关

2020-03-17 MedSci原创 MedSci原创

本研究旨在表征侵袭性牙周炎患者,慢性牙周炎患者和口腔健康个体的唾液微生物群。

本研究旨在表征侵袭性牙周炎患者,慢性牙周炎患者和口腔健康个体的唾液微生物群。

 

研究人员检查了侵袭性牙周炎患者(n = 31),慢性牙周炎患者(n = 25)和口腔健康对照组(n = 25)的唾液样本,总共81份。使用Illumina®MiSeqTM对16S rDNA基因的V1-V3区域进行测序,并将序列注释到扩展的人类口腔微生物组数据库(eHOMD)中。

 

结果显示,研究可以在物种水平上鉴定出平均百分比为97.6(范围:89.8–99.7)的序列。确定了包括牙龈卟啉单胞菌在内的七种细菌,且侵袭性牙周炎患者的唾液中的相对丰度明显高于口腔健康对照组的唾液中牙龈卟啉单胞菌的相对丰度。牙龈卟啉单胞菌的唾液丰度可以区分侵袭性(AUC:0.80,p = 0.0001)和慢性牙周炎(AUC:0.72,p = 0.006)与健康对照者。同样,牙龈卟啉单胞菌在唾液中的存在与侵袭性(p <0.0001,RR:8.1(95%CI 2.1-31.2))和慢性牙周炎(p = 0.002,RR:6.5(95%CI:1.6-25.9))显著相关。

 

总之,该研究结果表明,牙龈卟啉单胞菌在唾液中的存在和相对丰度与侵袭性和慢性牙周炎有关,但不能区分侵袭性和慢性牙周炎。

 

原始出处:

 

Christian DamgaardAnne Katrine Danielsen, et al., Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis. J Oral Microbiol. 2019; 11(1): 1653123. doi: 10.1080/20002297.2019.1653123

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    2020-12-19 xjy02
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    2020-05-18 sunylz
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createdBy=d59291, createdName=xjy02, createdTime=Sat Dec 19 17:11:35 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919019, encodeId=b99f191901961, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon May 18 11:11:35 CST 2020, time=2020-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020627, encodeId=de98202062e29, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Thu Apr 23 01:11:35 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857872, encodeId=00bf185e8724d, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Dec 20 08:11:35 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361079, encodeId=6b1c13610e930, content=<a 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451202, encodeId=29fc1451202cc, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536777, encodeId=3cd81536e7796, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26c712719796, createdName=photoman, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380596, encodeId=4ed8380596c3, content=厉害了真不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 17 00:35:13 CST 2020, time=2020-03-17, status=1, ipAttribution=)]
    2020-04-23 小几洁
  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451202, encodeId=29fc1451202cc, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536777, encodeId=3cd81536e7796, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26c712719796, createdName=photoman, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380596, encodeId=4ed8380596c3, content=厉害了真不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 17 00:35:13 CST 2020, time=2020-03-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1767748, encodeId=c4bc1e6774890, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Sep 21 08:11:35 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084577, encodeId=258c20845e704, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451202, encodeId=29fc1451202cc, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536777, encodeId=3cd81536e7796, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451202, encodeId=29fc1451202cc, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536777, encodeId=3cd81536e7796, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26c712719796, createdName=photoman, createdTime=Wed Mar 18 16:11:35 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380596, encodeId=4ed8380596c3, content=厉害了真不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 17 00:35:13 CST 2020, time=2020-03-17, status=1, ipAttribution=)]
    2020-03-18 sunyl07
  8. 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  9. 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  10. 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    2020-03-17 飛歌

    厉害了真不错

    0