PLoS Genet:吸烟会加快面部老化,你还敢吸烟吗?

2019-11-07 佚名 细胞

“吸烟脸”指的是吸烟者看起来比他们实际年龄大的一种状况。这是大量吸烟所造成的许多负面影响之一。最近,来自布里斯托大学的Louise Millard及其同事在发表于《 PLOS Genetics》杂志上的一项新研究中报告了这些发现。

“吸烟脸”指的是吸烟者看起来比他们实际年龄大的一种状况。这是大量吸烟所造成的许多负面影响之一。最近,来自布里斯托大学的Louise Millard及其同事在发表于《 PLOS Genetics》杂志上的一项新研究中报告了这些发现。

为了确定大量吸烟的带来的影响,科学家们希望将与吸烟有关的遗传变异以及与吸烟无关的遗传变异人为地分开。为了同时识别这两种类型的影响,研究人员使用了两种数据分析方法的组合,进而针对英国相关“生物库”中的数据进行分析。他们将人们分为两组。第一组包括从未吸烟的人,第二个包括目前正在吸烟或曾经有过吸烟史的人。

该分析搜索了18,000个特征,除了新发现的“吸烟者面部衰老更快“之外,还发现了先前报道的几种吸烟带来的影响。确定的吸烟会带来的已知影响包括肺功能恶化,以及患慢性阻塞性肺疾病(COPD)和皮肤癌等。

关于这项研究,作者Louise Millard说:“我们提出了一种新颖的方法,可用于探索影响健康的因果机制,并展示了这种方法在探究吸烟对身体健康的影响方面的能力。我们搜索了成千上万的特征以找出潜在的后果。除了确定一些已知的不利影响(例如对肺部健康),我们还发现了吸烟量增加对加快面部衰老的不利影响。”

原始出处:
Louise A. C. Millard, Marcus R. Munafò, Kate Tilling,et al. MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging. PLOS Genetics, 2019; 15 (10): e1008353 DOI: 10.1371/journal.pgen.1008353

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    2020-09-06 cy0324
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    2020-09-21 canlab
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