J Clin Periodontol:运动减轻牙周炎大鼠牙槽骨吸收和焦虑行为

2017-10-29 MedSci MedSci原创

本实验目的为评估体育训练对Wistar大鼠牙周病(PD)的炎症和行为的影响。

本实验目的为评估体育训练对Wistar大鼠牙周病(PD)的炎症和行为的影响。二十四只动物分布在2×2因子设计(有和没有运动,有和没有PD)。参与训练的动物在8周内每天游泳1小时。在实验结束前14天,通过结扎诱导PD,并且在最后一周,将所有动物进行Marble Burying Test。进行下颌骨的骨组织形态计量学分析及细胞因子表达的Western印迹法分析。我们还使用抗胶质纤维酸性蛋白抗体评估海马星形胶质细胞的形态测定。结果发现,身体训练使PD大鼠的骨吸收减轻和上皮附着水平丧失。患有PD的训练动物的牙周组织中TNF-α表达较低,而IL-10增加。训练有素的PD患者与诱导性牙周炎患者的TNF-α/ IL-10比值较低。 PD增加了患者的焦虑,而身体训练减弱了这一表现。运动增加没有PD的大鼠的海马星形胶质细胞。结论:运动减轻焦虑行为,炎症蛋白表达和PD大鼠的骨吸收。原始出处:Eric F. Andrade, et al. Exercise attenuates alveolar bone loss and anxiety-like behaviour in rats with period

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    2018-02-05 mei540
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    2018-05-30 feather89
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    2017-10-31 徐岩

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