Sci Tran Med:食盐过多降低身体抵抗力

2020-03-27 中国科学报 中国科学报

近日,一项研究表明,食盐过多可能会损害身体抵抗细菌感染的功能。

近日,一项研究表明,食盐过多可能会损害身体抵抗细菌感染的功能。

在实验中,德国波恩大学医院 Christian Kurts 团队发现,相比普通小鼠,高盐饮食的小鼠更难以抵抗因大肠杆菌引起的肾脏感染和因单核增生李斯特菌引起的全身感染。

“这些细菌在免疫系统清除它们之前,已对身体造成了很多伤害。” Kurts 表示。

接下来,研究小组开展人体测试。在正常饮食的基础上,10 名年龄在 20 到 50 岁之间的健康男女以每天 3 片的形式额外摄入 6 克盐。1 周后,与摄入前相比,他们的免疫性中性粒细胞吞噬和杀死细菌的能力大大减弱。研究小组没有研究高盐摄入对人体抵抗病毒感染能力的影响。

世界卫生组织建议,人们每天摄入的盐不能超过 5 克,以避免高血压和因此导致的中风和心脏病等。然而在英国,人们平均每天吃 8 克盐,这表明许多人与研究中的志愿者吃的盐一样多甚至更多。

为何食盐多会对身体造成伤害?研究小组认为这里面涉及两种机理。首先,食用大量盐后,身体会释放激素将盐分排出,其中就包括糖皮质激素,它具有抑制全身免疫系统的副作用。第二,肾脏会产生局部反应。研究发现,当盐分水平高时,尿素会在肾脏中累积,而尿素会抑制中性粒细胞,从而降低杀菌功能。

原始出处:

Katarzyna Jobin, Natascha E. Stumpf, Sebastian Schwab, et al. A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation. Science Translational Medicine 25 Mar 2020: Vol. 12, Issue 536, eaay3850. DOI: 10.1126/scitranslmed.aay3850.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1657305, encodeId=7b93165e30514, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Apr 22 12:23:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423683, encodeId=e8221423683d5, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610393, encodeId=7e4e1610393ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616318, encodeId=77eb161631898, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=)]
    2020-04-22 bsmagic9140
  2. [GetPortalCommentsPageByObjectIdResponse(id=1657305, encodeId=7b93165e30514, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Apr 22 12:23:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423683, encodeId=e8221423683d5, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610393, encodeId=7e4e1610393ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616318, encodeId=77eb161631898, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=)]
    2020-03-29 lingqf
  3. [GetPortalCommentsPageByObjectIdResponse(id=1657305, encodeId=7b93165e30514, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Apr 22 12:23:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423683, encodeId=e8221423683d5, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610393, encodeId=7e4e1610393ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616318, encodeId=77eb161631898, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1657305, encodeId=7b93165e30514, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Apr 22 12:23:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423683, encodeId=e8221423683d5, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610393, encodeId=7e4e1610393ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616318, encodeId=77eb161631898, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Sun Mar 29 04:23:33 CST 2020, time=2020-03-29, status=1, ipAttribution=)]

相关资讯

除了糖,这种常见的东西吃多了也容易得糖尿病!

一提到坏习惯,可能大家就会想到:吃了太多高糖分的食物。但是除了高糖,还有个隐形的杀手,却被大部分人忽略了,那就是——长期吃太多盐!

高血压病人到底该不该少吃盐?

大家都知道,少吃盐是控制血压的一项重要措施。那么是不是所有高血压病人都应该少吃盐?

J Nutr:美国研究:乳酪或可保护血管免受高盐的损害

宾夕法尼亚州立大学的一项新研究表明,奶酪中天然存在的抗氧化剂可能有助于保护血管免受饮食中高盐的损害。

Hypertension: 难治性高血压患者应加强醛固酮增多症筛查

与原发性高血压相比,难治性高血压与心血管疾病、肾脏疾病和死亡风险增加的相关性更高。尽管临床实践指南建议对难治性高血压进行原发性醛固酮增多症筛查,但尚无确切检出率。近期,Hypertension杂志发表研究对此进行分析。

BMJ:没有高血压者也该少吃盐

人每天对盐的生理需求量不到2.5 g,世界卫生组织建议成年人每人每天最多吃5 g盐,但很多人的盐摄入量远超这个数值。

全面利弊解析!生活方式如何影响心脏健康|GW-ICC2019

关于生活方式与心血管健康,看看GW-ICC2019大会上有哪些最新内容~