Exp Eye Res:氯化锂(LiCl)增加粒细胞角膜营养不良中的细胞自噬作用

2018-04-30 cuiguizhong MedSci原创

深圳市眼科医院的Nie D近日在Exp Eye Res发表了一篇文章,他们研究了氯化锂(LiCl)在粒状角膜营养不良(GCD)中,是否通过激活自噬途径来防止突变转化生长因子β诱导蛋白质(Mut-TGFBI)的细胞质积累。

深圳市眼科医院的Nie D近日在Exp Eye Res发表了一篇文章,他们研究了氯化锂(LiCl)在粒状角膜营养不良(GCD)中,是否通过激活自噬途径来防止突变转化生长因子β诱导蛋白质(Mut-TGFBI)的细胞质积累。

通过免疫组织化学(IHC)染色和Western印迹分析的方法,对3例GCD患者和健康对照中TGFBI和微管相关蛋白1A / 1B轻链3(LC3)的水平进行检测。分离原代角膜成纤维细胞,并用野生型或突变型TGFBI过表达载体转染,然后用LiCl或自噬抑制剂3-甲基腺嘌呤(3-MA)处理。检测TGFBI、糖原合酶激酶-3(GSK-3)和LC3-I /-II的水平。此外,进行细胞活力和透射电子显微镜检测。

研究发现,GCD患者中TGFBI和LC3的水平显着增加。突变型TGFBI的过度表达抑制了角膜成纤维细胞的细胞活力,并引起自噬作用。在突变型TGFBI过表达细胞中,LiCl以剂量和时间依赖性的方式下调TGFBI的表达。在突变型TGFBI过表达细胞中,LiCl也增强了自噬过程,并恢复那些细胞的细胞活力。然而,当自噬被3-MA抑制时,LiCl的作用部分减弱。

因此,他们认为,用LiCl处理可抑制TGFBI的表达,并部分通过增强自噬作用来恢复突变型TGFBI的细胞活力。这些数据强烈表明,LiCl可以用于治疗GCD。

原文出处:

Nie, D., et al., Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Exp Eye Res, 2018.

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    2018-11-11 DEXTER3150
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    2018-05-02 snowpeakxu
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    2018-05-01 飛歌

    厉害了我的哥

    0