Hypertension:机器学习方法在预测年轻高血压患者临床结局的价值

2020-03-16 MedSci原创 MedSci原创

由此可见,ML法与Cox回归法在判断年轻高血压患者临床预后方面效果相当,而优于重新校准的Framingham风险评分模型。

年轻高血压患者的危险分层仍然具有挑战性,一般来说,机器学习(ML)被认为是一个有前景的替代传统方法的临床预测手段,因为它能够处理大量复杂的数据。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员探索了ML方法预测年轻高血压患者预后的可行性,并将其与目前临床常用的方法进行了比较。

研究人员评估了508名曾在三级医院接受治疗的年轻高血压患者(30.83±6.17岁)基线临床数据和包含全因死亡、急性心肌梗死、冠状动脉血管再通、新发心力衰竭、新发房颤/房扑、持续的室性心动过速或室颤、外周动脉血管再通、新发卒中和终末期肾脏疾病的复合终点。在33个月的随访评估中,研究人员构建了包含递归特征消除、极端梯度增强和10倍交叉验证的ML模型,并将该模型的性能与Cox回归和重新校准的Framingham风险评分模型进行了比较。

11个变量的组合被认为是使用ML方法预测患者结局更有价值。ML模型识别复合终点患者的C统计量为0.757 (95%CI为0.660-0.854),而Cox回归模型和重新校准的Framingham风险评分模型的C统计量分别为0.723(95%CI为0.636-0.810)和0.529(95%CI为0.403-0.655)。

由此可见,ML法与Cox回归法在判断年轻高血压患者临床预后方面效果相当,而优于重新校准的Framingham风险评分模型。

原始出处:

Xueyi Wu.et al.Value of a Machine Learning Approach for Predicting Clinical Outcomes in Young Patients With Hypertension.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13404

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    2020-11-01 feather89
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