Semin Arthritis Rheu:伴COPD的类风湿性关节炎患者中阿巴西普的安全性

2019-04-24 xiangting MedSci原创

类风湿性关节炎(RA)的阿巴西普安全性ASSURE随机试验报道称,在54例慢性阻塞性肺病(COPD)的患者亚组中,阿巴西普的呼吸道不良反应更常见,这导致了标签警告。这项研究评估了在现实世界的观察环境中与其他生物性DMARDs(bDMARDs)相比,伴COPD的RA患者与阿巴西普相关不良呼吸事件的风险。研究人员在2007至2014年的美国MarketScan数据库中组建了一个新用户队列,纳入使用bD

类风湿性关节炎(RA)的阿巴西普安全性ASSURE随机试验报道称,在54例慢性阻塞性肺病(COPD)的患者亚组中,阿巴西普的呼吸道不良反应更常见,这导致了标签警告。这项研究评估了在现实世界的观察环境中与其他生物性DMARDs(bDMARDs)相比,伴COPD的RA患者与阿巴西普相关不良呼吸事件的风险。

研究人员在2007至2014年的美国MarketScan数据库中组建了一个新用户队列,纳入使用bDMARD治疗伴COPD的RA患者。阿巴西普使用者根据时间条件倾向评分与其他bDMARDs使用者进行匹配。使用Cox模型,估算比较阿巴西普与其他bDMARDs不良呼吸事件的调整风险比(HRs)和95%置信区间(CIs)。

该队列包括1807名阿巴西普初始使用者和3547名匹配的其他bDMARD初始使用者。与其他bDMARDs相比,住院COPD 恶化、支气管炎和院内肺炎或阿巴西普相关流感的联合终点HR 为0.87(95%CI:0.68-1.12)。住院COPD恶化的HR为0.60(95%CI:0.32-1.11),支气管炎为0.80(95%CI:0.56-1.14)。而对于肺炎或流感,如果住院治疗为1.39(95%CI:0.91-2.13),门诊治疗为1.05(95%CI:0.86-1.29)。

这项来自现实世界的大型安全性研究发现,与其他bDMARDs相比,在伴COPD的RA患者中阿巴西普不会增加不良呼吸道事件的风险。这项研究未证实较小的ASSURE试验提出的安全性信号。

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    2019-04-26 lmm397
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    2019-04-26 zhaojie88
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