JAMA Pediatr:乳喂养更好?能保护新生儿免受感染!

2018-05-06 悠然 生物探索

都说母乳喂养好处多多,现在科学家们又找到了证明这一观点的新证据!原来,女性的母乳中含有能够抵抗入侵者(如细菌)的免疫细胞——先天淋巴细胞(innate lymphoid cells,ILCs)。


图片来源:JAMA Pediatrics(doi:10.1001/jamapediatrics.2018.0148)

4月9日,发表在JAMA Pediatrics上的题为“Presence and Profile of Innate Lymphoid Cells in Human Breast Milk”的研究中,来自奥古斯塔大学的科学家们发现,短期内,母乳中的ILCs可能有助于保护新生儿免受感染;长期来说,ILCs还能够帮助婴儿形成他们自己的保护性免疫系统。

参与该研究的Jack Yu博士说:“母乳中含有数百万个细胞,包括许多类型的免疫细胞,但ILCs也存在于母乳中似乎是首次被报道。”

事实上,经过先前约10年的研究,科学家们已经证实,ILCs在炎症、免疫和组织稳态中有重要的作用。在这项新研究中,论文的通讯作者兼第一作者Babak Baban博士带领的团队对4名哺乳期女性的新鲜母乳进行了广泛的细胞分析。

结果显示,新鲜的人类母乳中包含了已知的3种ILCs,其中1型ILCs(type 1)最为普遍。平行的小鼠研究表明,这些细胞不仅通过哺乳传递给了婴儿,而且在婴儿的肠道中存活了至少好几天。


图片来源:16sucai

那么,ILCs进入婴儿的肠道后会发生什么?它们将如何(或者是否能)帮助调整婴儿的微生物组(microbiome,帮助消化及对抗感染)呢?初步的研究结果显示,ILCs是构建微生物组的一个“参与者”,其中,ILC3s能够帮助形成肠道的保护性黏膜层。

总结来说,作者们认为,母乳中的ILCs有助于为婴儿提供第一线的免疫保护,同时,这些细胞可能也是保护母亲免受感染的一种方式。ILCs的存在为证明母乳喂养的益处提供了更多的证据。

原始出处:

Babak Baban, Aneeq Malik, Jatinder Bhatia, et.al. Presence and Profile of Innate Lymphoid Cells in Human Breast Milk. JAMA Pediatrics April 9, 2018

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    2018-05-09 易水河

    母乳喂养好

    0

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    2018-05-07 orangesking

    0

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    2018-05-06 易水河

    母乳喂养好

    0

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    2018-05-06 1e0f8808m18(暂无匿称)

    母乳喂养是新生儿**的食物.

    0

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    2018-05-06 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-05-06 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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现今为止,我们对于母体免疫反应在耐受诱导中的作用还知之甚少。为了研究母体过敏原致敏是否会影响子代对食物过敏的易感性,来自波士顿儿童医院的研究人员利用卵清蛋白(OVA)对表皮敏感的雌性小鼠进行表皮致敏,而后用OVA的表皮致敏和口服来刺激它们的后代。

JAMA Intern Med:30年随访证实6个月以上母乳喂养即可大幅降低母亲糖尿病风险

研究通过纵向生化证据证实,母乳喂养可大大降低母亲的糖尿病风险,持续6个月以上的母乳喂养即可获得最大的糖尿病风险降低收益