Cell:治愈脊髓损伤新疗法

2018-03-02 小通 生物通

中枢神经系统的愈合能力非常有限,大脑或脊髓损伤常常导致永久性功能障碍。瑞典Karolinska学院的研究人员直击神经愈合关键,改善了小鼠脊髓损伤后的功能恢复。


中枢神经系统的愈合能力非常有限,大脑或脊髓损伤常常导致永久性功能障碍。瑞典Karolinska学院的研究人员直击神经愈合关键,改善了小鼠脊髓损伤后的功能恢复。

许多器官的受损组织都可以自发的新生细胞替换修复,然而,中枢神经系统受损失后,一种特殊类型的疤痕组织会抑制再生。因此,阻碍脑和脊髓损伤修复。

一个多世纪以前,人们就意识到中枢神经系统的神经纤维不能从损害后形成的疤痕组织中恢复生长。疤痕组织是由不同细胞和分子组成的复杂网络,长期以来科学家们都未找到疤痕组织阻止神经纤维再生的真正原因。如今,Karolinska学院的研究人员终于发现了抑制神经纤维再生的一个重要机制。

“该发现指出了限制中枢神经系统损伤后修复的关键,”细胞和分子生物学系副教授Christian G?ritz说。

他们在生成一大块疤痕组织的血管细胞中找到了一小群特殊细胞,这些血管相关细胞能抑制疤痕形成,从而使一些经历损伤后的神经纤维重新生长,并与其他神经细胞建立连接,最终导致了小鼠脊髓损伤后的功能恢复。

“继续探索这方面知识将有助于促进人类中枢神经系统损伤患者治疗,这是我们下一步研究计划,”Christian G?ritz。

原始出处:

David Oliveira Dias, etal.Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.Cell.Published online: March 1, 2018

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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-04-17 维他命
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    2018-03-08 Drhzm308

    好的.学习了

    0

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objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Mar 03 08:07:11 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292503, encodeId=b50729250310, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Mar 03 07:49:38 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292462, encodeId=7b6d292462c4, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-05 Ramsey

    学习了

    0

  5. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
  6. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-04 kcb074
  7. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-03 耳朵里的阳光I

    谢谢分享

    0

  8. 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level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58559, encryptionId=74e458559f5, topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Sun Mar 04 11:34:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292546, encodeId=e95129254643, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ5Wh2AdV0pAHwuiadWmnZib4Ay8MSrGtiaoLlThlm9thFVLSVPQgknybSa56ibCQicR8lcEnd3F5HjYBA/0, createdBy=52932154723, createdName=耳朵里的阳光I, createdTime=Sat Mar 03 09:14:55 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292515, encodeId=8b2429251528, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Mar 03 08:07:11 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292503, encodeId=b50729250310, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Mar 03 07:49:38 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292462, encodeId=7b6d292462c4, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-03 半夏微凉

    学习了谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1960746, encodeId=238f1960e461e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Apr 17 17:34:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870478, encodeId=6c3c18e047881, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, 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level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58559, encryptionId=74e458559f5, topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Sun Mar 04 11:34:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292546, encodeId=e95129254643, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ5Wh2AdV0pAHwuiadWmnZib4Ay8MSrGtiaoLlThlm9thFVLSVPQgknybSa56ibCQicR8lcEnd3F5HjYBA/0, createdBy=52932154723, createdName=耳朵里的阳光I, createdTime=Sat Mar 03 09:14:55 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292515, encodeId=8b2429251528, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Mar 03 08:07:11 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292503, encodeId=b50729250310, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Mar 03 07:49:38 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292462, encodeId=7b6d292462c4, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-03 121832a9m88暂无昵称

    学习了

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Mar 03 08:07:11 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292503, encodeId=b50729250310, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Mar 03 07:49:38 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292462, encodeId=7b6d292462c4, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 03 07:14:26 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-03 yjs木玉

    好好好好好好好好

    0

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当皮肤、骨骼、口腔黏膜等部位受伤时,因为损伤区有利于再生微环境的产生,只需要一段时间的治疗这些部位就能再生愈合,并且恢复到健康状态。然而,损伤的脊髓部位形成不利于神经再生的微环境,神经再生很难发生。因此,脊髓损伤被认为是难治愈的疾病。

中国医师协会骨科医师分会骨科循证临床诊疗指南:成人急性下颈段脊柱脊髓损伤循证临床诊疗指南

为了给中国的骨科医师提供关于急性下颈段脊柱脊髓损伤的临床诊疗指南,中国医师协会骨科医师分会脊柱创伤工作组组织相关专家撰写了本指南。本指南适用于3周内的成人外伤性下颈段(颈3~颈7)椎体的骨折和(或)脱位,伴或不伴有脊髓、神经根损伤。工作组通过设置问题、确定检索词来检索中英文文献,按照纳入和排除标准筛选文献;然后详细分析最终纳入的证据文献,确定证据等级,给出相应的推荐建议。本指南最终纳入了141篇文