Arthritis Rheumatol:肠道微生物通过粘膜炎症和产生自身抗体调节炎症性关节炎

2018-03-18 xiangting MedSci原创

这些数据支持一种模型,其中肠道微生态失调引发黏膜免疫反应,从而刺激作为炎症性关节炎出现关键的T细胞和B细胞。

目前对RA患者微生物菌群失调的观察引发了研究微生物-粘膜相互作用作为RA潜在触发因素的兴趣。使用鼠胶原诱导的关节炎(CIA)模型,研究人员假设微生物群调节免疫应答,从而导致自身免疫性关节炎。

在第0天和第21天用佐剂中的II型胶原(CII)免疫诱导小鼠CIA,关节炎出现在第23-24天。在CIA病程中,每7天通过16S rRNA测序对肠道微生物群进行分析,并在第14和35天评估肠粘膜改变。然后,在CIA早期(前7天)或后期(21天后)注射广谱抗生素消除微生物群。在微生物减少的情况下,监测疾病严重程度、自身抗体全身细胞因子产生以及肠粘膜反应。

显著的生态失调和粘膜炎症发生在CIA早期,早于可见关节炎,并在疾病过程中继续发展。诱导CIA之前消除微生物群可以导致疾病严重程度降低?40%,并显著降低血清炎性细胞因子和抗CII抗体。在肠组织中,IL-17A和IL-22产生延迟。出乎意料的是,CIA后期的微生物消除导致疾病严重程度降低> 90%。抗CII抗体轻度降低,但由于改变的糖基化特征其激活补体的能力降低。

这些数据支持一种模型,其中肠道微生态失调引发黏膜免疫反应,从而刺激作为炎症性关节炎出现关键的T细胞和B细胞。

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    2018-05-01 guoyibin
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    2018-03-21 changjiu

    学习一下谢谢

    0

  5. 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time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547123, encodeId=cf22154e12371, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Mar 20 00:59:00 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297380, encodeId=bbe929e38079, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Mar 18 10:31:33 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297371, encodeId=547229e371ca, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Mar 18 10:14:28 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-20 lmm397
  6. 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    2018-03-20 zhaojie88
  7. 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  8. 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    2018-03-18 changjiu

    学习一下谢谢

    0

  10. 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    2018-03-18 龙胆草

    学习谢谢分享

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