J Allergy Clin Immunol Pract:大多数学龄前过敏的儿童在成年前会发展为过敏性疾病

2021-11-21 AlexYang MedSci原创

调查了19岁时哮喘和鼻炎的累积发病率与对气传过敏原致敏时的年龄之间的关系。

过敏反应会增加哮喘和过敏性鼻炎的风险,但对过敏反应开始时的年龄对今后的影响研究较少。

近期,来自瑞典的研究人员在《J Allergy Clin Immunol Pract》上发表文章,调查了19岁时哮喘和鼻炎的累积发病率与对气传过敏原致敏时的年龄之间的关系

研究对象包括瑞典北部两个城市的所有一、二年级的儿童(中位年龄为8岁),研究人员对参与的儿童进行了皮肤点刺试验和有关过敏性疾病的问卷调查,其中88%的儿童参加了调查。在12岁和19岁时,再次进行皮肤点刺试验和有关过敏性疾病的问卷调查。其中,共有1510人参加了所有三次检查。在19岁时随机调查了特异性IgE,n=770。过敏开始年龄分为:≤8岁,8-12岁,12-19岁,以及从未过敏过。利用调整后的泊松回归计算了风险比。

结果表明,19岁时,致敏发生时≤8岁的儿童中,他们患哮喘(RR 4.68(95%CI 3.14-6.97))和鼻炎(RR 22.3(95%CI 13.3-37.6))的风险最高,其中84%的参与者已经发展成哮喘或鼻炎。致敏发生时的年龄≤8岁和过敏性疾病家族史的组合使哮喘(RR10.6(6.71-16.7))和鼻炎(RR36.3(18.9-69.7)发生的风险很高。根据皮肤测试的阳性数量和特异性IgE的滴度判断,致敏≤8岁的儿童显示出了最高的敏感水平。

19岁时的哮喘和鼻炎风险情况

综上所述,大多数致敏≤8岁的参与者在刚成年时就已患上哮喘或鼻炎。早期致敏者的高敏感水平导致了过敏性气道疾病的高发病率

原始出处:

Joakim Bunne , Linnea Hedman , Matthew Perzanowski et al. The majority of children sensitized before school-age develop allergic disease before adulthood: a longitudinal population-based study. J Allergy Clin Immunol Pract. Oct 2021

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2047454, encodeId=5712204e4540a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Feb 27 11:46:17 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076756, encodeId=7daa10e6756e9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710b4868428, createdName=爱吃芒果vv, createdTime=Sat Dec 04 09:56:42 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329576, encodeId=d40013295e6a5, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 23 01:46:17 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072777, encodeId=0d9c10e2777f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erYZdOrGG9XibsiagmWn4A0tUVncxNonDoZMDc4sgOhz2icOGEBhtChcTEprALT5UBVxlLJSazhIKLVA/132, createdBy=b9ae5253154, createdName=Elfin3915, createdTime=Mon Nov 22 10:46:18 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072568, encodeId=663b10e256822, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba15692250, createdName=ms2000000622566662, createdTime=Sun Nov 21 17:54:52 CST 2021, time=2021-11-21, status=1, ipAttribution=)]
    2021-12-04 爱吃芒果vv

    学习了

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    2021-11-23 膀胱癌
  4. [GetPortalCommentsPageByObjectIdResponse(id=2047454, encodeId=5712204e4540a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Feb 27 11:46:17 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076756, encodeId=7daa10e6756e9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710b4868428, createdName=爱吃芒果vv, createdTime=Sat Dec 04 09:56:42 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329576, encodeId=d40013295e6a5, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 23 01:46:17 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072777, encodeId=0d9c10e2777f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erYZdOrGG9XibsiagmWn4A0tUVncxNonDoZMDc4sgOhz2icOGEBhtChcTEprALT5UBVxlLJSazhIKLVA/132, createdBy=b9ae5253154, createdName=Elfin3915, createdTime=Mon Nov 22 10:46:18 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072568, encodeId=663b10e256822, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba15692250, createdName=ms2000000622566662, createdTime=Sun Nov 21 17:54:52 CST 2021, time=2021-11-21, status=1, ipAttribution=)]
    2021-11-22 Elfin3915

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2047454, encodeId=5712204e4540a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Feb 27 11:46:17 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076756, encodeId=7daa10e6756e9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710b4868428, createdName=爱吃芒果vv, createdTime=Sat Dec 04 09:56:42 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329576, encodeId=d40013295e6a5, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 23 01:46:17 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072777, encodeId=0d9c10e2777f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erYZdOrGG9XibsiagmWn4A0tUVncxNonDoZMDc4sgOhz2icOGEBhtChcTEprALT5UBVxlLJSazhIKLVA/132, createdBy=b9ae5253154, createdName=Elfin3915, createdTime=Mon Nov 22 10:46:18 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072568, encodeId=663b10e256822, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba15692250, createdName=ms2000000622566662, createdTime=Sun Nov 21 17:54:52 CST 2021, time=2021-11-21, status=1, ipAttribution=)]
    2021-11-21 ms2000000622566662

    学习了

    0

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