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Diabetologia：家族糖尿病状况和诊断年龄对2型糖尿病风险的影响：基于丹麦全国登记研究

2020-07-20 MedSci原创 MedSci原创

家族；糖尿病状况
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本研究评估了患2型糖尿病的风险和发病年龄是否与患病家庭成员的糖尿病诊断年龄有关。我们对1995年至2012年居住在丹麦的个人进行了一项基于国家注册表的公开队列研究。

本研究评估了患2型糖尿病的风险和发病年龄是否与患病家庭成员的糖尿病诊断年龄有关。我们对1995年至2012年居住在丹麦的个人进行了一项基于国家登记的公开队列研究。参与研究的人群包括所有30岁或以上的个人，他们在队列开始时(1995年1月1日)没有诊断为糖尿病，并且有关于其父母身份的信息。在观察期间已满30岁且拥有父母身份信息的个体也从该日期起加入队列(公开队列设计)。这些标准将研究人群限定为主要是1960年至1982年之间出生的人。采用多变量泊松回归模型(根据当前年龄和最高教育程度进行调整)来估计2型糖尿病的发病率比(IRRs)。 我们共计随访了2,000,552人，平均随访时间14年(24,034,059人年)，并观察了76,633例2型糖尿病的新病例。与没有父母或兄弟姐妹患有糖尿病的同龄或同性别的人相比，家庭成员在早年就被诊断出患2型糖尿病的风险最高。家庭成员的糖尿病诊断年龄越高，IRR越低:父母年龄分别为50岁和80岁的患者的IRR分别为3.9比1.4;和3.3 vs 2.0，对于那些有兄弟姐妹的诊断年龄分别为30岁或60岁的患者。 与家庭成员在晚年被诊断出糖尿病的人相比，家庭成

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    2021-03-21 360611849

    #诊断年龄#

    0

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    2021-04-28 ms3994565386320060

    #2型糖尿病风险#

    0

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    2021-02-21 ms5439512287675881

    #BET#

    0

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    2020-07-29 ms9608593228839890

    #DIA#

    0

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    2020-07-20 gq1688888

    评论

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1681942, encodeId=8a76168194247, content=<a href='/topic/show?id=19939159231' target=_blank style='color:#2F92EE;'>#诊断年龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91592, encryptionId=19939159231, topicName=诊断年龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cf527881568, createdName=360611849, createdTime=Sun Mar 21 01:10:08 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956330, encodeId=91af1956330d7, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Wed Apr 28 11:10:08 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761446, encodeId=bc801e614460e, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Feb 21 10:10:08 CST 2021, time=2021-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639522, encodeId=00e5163952218, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jul 29 07:10:08 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803522, encodeId=2c04803522e4, content=评论, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/24/44b8702a305feef6e9b555c4dada4a75.jpg, createdBy=15402510012, createdName=gq1688888, createdTime=Mon Jul 20 20:01:39 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043228, encodeId=f646104322885, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 17:10:08 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 misszhang

    谢谢MedSci提供最新的资讯

    0