Int J Mol Sci:ATPS mAb标记Zr-89,可用于肿瘤血管生成的免疫-PET成像

2020-04-23 网络 网络

本研究中,我们合成了一种Zr-89标记的抗腺苷三磷酸合酶单克隆抗体(ATPS mAb),用于免疫-positron发射断层扫描(PET),并评估了其在血管生成成像中的可行性。

本研究中,我们合成了一种Zr-89标记的抗腺苷三磷酸合酶单克隆抗体(ATPS mAb),用于免疫-positron发射断层扫描(PET),并评估了其在血管生成成像中的可行性。

 

对Zr-89 ATPS mAb在体外处理癌细胞株后的细胞摄取量进行了测定,并对其在小鼠体内4、24和48 h时的生物分布进行了评估。在Zr-89 ATPS mAb给药后的4,24,48和96 h获得PET图像。使用抗CD31免疫荧光染色分析肿瘤血管生成。

 

结果显示,在MDA-MB-231乳腺癌细胞中,Zr-89 ATPS mAb的细胞摄取量随着时间的推移而增加,但在PC3前列腺癌细胞中没有增加。MDA-MB-231细胞在24 h时对Zr-89 ATPS mAb的肿瘤吸收率为9.4±0.9% ID/g,PC3细胞为3.8±0.6% ID/g(p = 0.004)。Zr-89 ATPS mAb在MDA-MB-231异种移植细胞中的吸收被冷ATPS mAb给药所抑制(4.4±0.5% ID/g,p = 0.011)。在MDA-MB-231肿瘤中,Zr-89 ATPS mAb的摄取可以通过PET可视化,长达96 h。相比之下,在PC3异种移植模型中,没有明显的肿瘤吸收通过PET检测到明显的肿瘤吸收。CD31阳性的肿瘤血管在MDA-MB-231肿瘤中大量存在,而在PC3肿瘤中几乎没有检测到。

 

总之,ATPS mAb成功标记了Zr-89,可用于肿瘤血管生成的免疫-PET成像。

 

原始出处:

 

Bok-Nam ParkGa-Hee Kim, et al., Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis. Int J Mol Sci. 2019 Aug; 20(16): 3928.  doi: 10.3390/ijms20163928

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    2020-06-08 feather89
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    2020-12-15 snf701207
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    2020-04-25 listen320

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