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Nature commu：科学家发现癌基因STAT3竟也可抑癌？！

2015-07-27 佚名 生物谷

癌基因STAT3
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近日，来自奥地利维也纳医科大学的研究人员发现，通常在癌症中发挥癌基因作用的IL-6和STAT3信号途径在前列腺癌中发挥着不同的作用。相关研究结果发表在国际学术期刊nature communication上。

IL-6是一种重要的细胞因子，它在调控细胞存活和肿瘤生长方面发挥着重要作用。高活性的IL-6会促进肿瘤生长，而STAT3是其下游一个重要的效应因子，在许多类型的癌症中扮演着癌基因的作用。目前已经有许多靶向抑制IL-6和STAT3的治疗方法用于癌症治疗。
 
但根据这项研究的结果来看，IL-6和STAT3在前列腺癌中发挥的作用与人们以往的认识有些不同，研究人员发现，在前列腺癌细胞中，激活的STAT3能够激活ARF基因，阻断细胞分裂进而抑制细胞生长。
 
在这项研究中，研究人员在Pten缺失的前列腺癌小鼠模型中，在基因水平抑制了STAT3或IL-6信号途径，结果发现该信号途径失活可以加速癌症进展并导致癌转移。他们发现p19ARF是STAT3的一个直接靶向目标，STAT3信号途径缺失会扰乱ARF-Mdm2-p53这条肿瘤抑制因子轴，但不会影响细胞衰老。除此之外，研究人员还在人类前列腺癌细胞中发现了STAT3和CDKN2A突变，并且STAT3和CDKN2A缺失突变在转移性前列腺癌细胞中共发生频率非常高。
 
研究人员还发现，STAT3和p14ARF在病人前列腺肿瘤中缺失与前列腺癌复发和转移风险增加存在显著相关性。因此STAT3和ARF表达水平或可用作区分前列腺癌发生风险高低的诊断标记。
 
总的来说，这项研究发现在其它类型的癌症中发挥癌基因作用的STAT3在前列腺癌中发挥抑癌作用，并且这种抑癌作用是通过调节ARF的表达影响ARF-Mdm2-p53肿瘤抑制因子轴的作用实现的。STAT3以及ARF的表达水平或可用于预测前列腺癌风险，可以得到进一步开发应用。
 
原始出处
 
Pencik J1, Schlederer M2, Gruber W3, Unger C4.et.al.STAT3 regulated ARF expression suppresses prostate cancer metastasis.Nat Commun. 2015 Jul 22

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    2015-10-26 liye789132251

    #Nat#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1880749, encodeId=58331880e49b5, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Oct 26 20:28:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802279, encodeId=eedb18022e91a, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sun Aug 30 00:28:00 CST 2015, time=2015-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640647, encodeId=2b21164064ebd, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Sat Jun 18 00:28:00 CST 2016, time=2016-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33712, encodeId=299633e1208, content=很多因子,通路在肿瘤中的作用都是双向的！, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Wed Jul 29 09:38:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33708, encodeId=108633e08c2, content=我去！, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Wed Jul 29 02:58:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348954, encodeId=cb35134895445, content=<a href='/topic/show?id=684f16e52c8' target=_blank style='color:#2F92EE;'>#STAT3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16752, encryptionId=684f16e52c8, topicName=STAT3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jul 29 00:28:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373881, encodeId=be2413e38817a, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee7b365, createdName=zhucaizhong7766, createdTime=Wed Jul 29 00:28:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33559, encodeId=b2bd33559be, content=最近总出这样的文章啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150718/IMG55A9FB2B517AF5482.jpg, createdBy=0bf992515, createdName=yeyunmeng, createdTime=Mon Jul 27 10:25:00 CST 2015, time=2015-07-27, status=1, ipAttribution=)]
    2015-08-30 旅苦化文_208

    #科学家发现#

    0

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    2016-06-18 jingyanzhu715_39486108

    #抑癌#

    0

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    2015-07-29 Jianghuiqin

    很多因子,通路在肿瘤中的作用都是双向的！

    0

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    2015-07-29 shenyifeiyang

    我去！

    0

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    2015-07-29 仁医06

    #STAT3#

    0

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    2015-07-29 zhucaizhong7766

    #癌基因#

    0

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    2015-07-27 yeyunmeng

    最近总出这样的文章啊

    0