IBD:药物治疗监测可提高小儿克罗恩病患者抗肿瘤坏死因子α药物的保留率

2020-08-03 MedSci原创 MedSci原创

近年来,抗肿瘤坏死因子α(anti-TNFα)药物的治疗药物监测(TDM)已被广泛使用。本项研究旨在研究其对克罗恩病(CD)小儿患者长期药物保留和临床结局的影响。

背景

近年来,抗肿瘤坏死因子α(anti-TNFα)药物的治疗药物监测(TDM)已被广泛使用。本项研究旨在研究其对克罗恩病(CD)小儿患者长期药物保留和临床结局的影响。

方法

研究人员回顾性分析了2007年至2018年接受抗TNFα药物治疗的小儿CD患者的病历。患者分为在2007年至2012年之间开始抗TNFα治疗的患者(当时没有TDM(TDM-)的时代)以及在2013年至2018年之间开始抗TNFα治疗的患者,有TDM的时代(TDM +)。主要结局指标包括首次抗TNFα终止治疗的时间(药物保留),复发和每年首次抗TNFα治疗的住院率和手术切除率。

结果

本项研究纳入197例患者(n = 98,TDM-; n = 99,TDM +)。与TDM-组相比,TDM +组的药物保留时间更长(45.0±2.7 vs 33.5±2.4个月;P = 0.001),每位患者每年的住院率较低(0.51±0.7 vs. 0.92±0.81;P <0.001)和更高的治疗强化率(70%vs 18%;P <0.001)。手术切除率无明显差异。整个队列的分析显示,阿达木单抗和英夫利昔单抗的保留时间更长(45.3±2.8 vs 34.8±2.5个月;P = 0.007)。

结论

基于TDM的治疗可延长药物保留时间,从而更好地利用抗TNFα药物,并具有其他一些有利的结果。

原始出处 :

Yoel Gofin. Et al. Therapeutic Drug Monitoring Increases Drug Retention of Anti–Tumor Necrosis Factor Alpha Agents in Pediatric Patients With Crohn’s Disease. Inflammatory Bowel Diseases.2020.

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    2020-08-06 chenny

    学习了

    0

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    2020-08-05 bnurmamat
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    2020-08-05 millore
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