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AsiDNA 治疗晚期实体瘤的I期临床试验正式启动

2018-04-25 MedSci MedSci原创

AsiDNA晚期实体瘤I期临床
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一种专门研究肿瘤学创新药物的生物技术公司Onxeo近日宣布，其旗下的 AsiDNA™（针对罕见或耐药肿瘤细胞的DNA修复抑制剂）正式进入I期临床阶段。该研究的目的是评估AsiDNA™的安全性并确定其在晚期实体癌患者治疗中的最佳临床剂量。

一种专门研究肿瘤学创新药物的生物技术公司Onxeo近日宣布，其旗下的 AsiDNA™（针对罕见或耐药肿瘤细胞的DNA修复抑制剂）正式进入I期临床阶段。该研究的目的是评估AsiDNA™的安全性并确定其在晚期实体癌患者治疗中的最佳临床剂量。

AsiDNA™具有独特的创新性作用机制，能够通过抑制参与肿瘤DNA损伤修复的酶来抑制肿瘤DNA损伤的修复，从而使其无法修复受损的染色体，这能够导致肿瘤细胞的死亡。对癌症治疗的DNA损伤应答方法的研究是一个非常引人注目的课题，目前已有PARP抑制剂的获得了FDA的批准，AsiDNA™具有独特的作用机制和为患者提供更有吸引力的治疗选择的潜力。

Onxeo首席执行官Judith Greciet表示，“虽然AsiDNA™在先前试验中（直接注入肿瘤）已经显示出临床活性，但通过全身给药来探究类似的活性将提供大量的肿瘤治疗的机会。我们期待在第一阶段的临床试验中评估AsiDNA™，以便在系统给药时确定这种有希望的候选产品的临床益处”。

原始出处：

http://www.firstwordpharma.com/node/1559537?tsid=4#axzz5DdyMTt4V

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