NEJM:这样的指甲改变,你见过吗?

2018-10-21 医咖会 医咖会

患者,男,42岁,近期正在接受非霍奇金淋巴瘤的治疗,因指甲变化被送往肿瘤科就诊。5个月前,患者诊断为B细胞非霍奇金淋巴瘤,之后完成了4个周期的化疗,治疗药物包括利妥昔单抗、依托泊苷、泼尼松、长春新碱、环磷酰胺和阿霉素。患者的血清白蛋白水平为2.5g/dl(参考范围:3.5-5.0)。体格检查显示患者指甲弥漫性、深褐色变色(黑甲),伴有两种类型的横向白线。指甲上不透明的横线(长剪头所指)称为米氏线(

患者,男,42岁,近期正在接受非霍奇金淋巴瘤的治疗,因指甲变化被送往肿瘤科就诊。

5个月前,患者诊断为B细胞非霍奇金淋巴瘤,之后完成了4个周期的化疗,治疗药物包括利妥昔单抗、依托泊苷、泼尼松、长春新碱、环磷酰胺和阿霉素。



患者的血清白蛋白水平为2.5g/dl(参考范围:3.5-5.0)。体格检查显示患者指甲弥漫性、深褐色变色(黑甲),伴有两种类型的横向白线。指甲上不透明的横线(长剪头所指)称为米氏线(Mees' lines),更多的半透明横线(短箭头所指)称为Muehrcke线。

米氏线是由于指甲基质受损而产生,而Muehrcke线则与异常的甲床血管系统有关。米氏线不会随着按压指甲而消失,而Muehrcke线会消失。

多种化疗药物与这些指甲改变有关。Muehrcke线也可能发生在低蛋白血症患者中。

经过6个周期的化疗后,患者的非霍奇金淋巴瘤缓解。化疗结束6个月后,指甲变化完全消失。

参考文献:N Engl J Med 2018; 379:1561

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    2019-05-04 ycmayy
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    2018-10-22 lietome2

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

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    2018-10-22 明月清辉

    谢谢分享,学习了

    0

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    2018-10-22 飛歌

    學習了很有用不錯

    0

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    2018-10-21 医者仁心5538

    学习了

    0

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