Neuroradiology:糖尿病视网膜病变患者脑功能网络与临床指标的相关性

2017-09-12 shaosai MedSci原创

目前,糖尿病视网膜病变(DR)患者的脑功能网络参数和临床指标的关系尚不明确,本研究旨在验证两者之间的关系,并将结果发表在Neuroradiology上。

目前,糖尿病视网膜病变(DR)患者的脑功能网络参数和临床指标的关系尚不明确,本研究旨在验证两者之间的关系,并将结果发表在Neuroradiology上。

本研究自2012年8月至2014年9月共纳入了21例不同期DR患者和21名年龄、性别相匹配的健康志愿者。临床指标记录包括DR分期、糖尿病病程、HbA1c、糖尿病筛查、空腹血糖、胰岛素、Homa-β、Homa-IR、胰岛素敏感指数(ISI)、简易精神状态检查(MMSE)、性别和年龄。受试者接受3T MR 血氧饱和水平依赖序列和3D-FSPGR序列。在处理前和功能网络重建后对MR数据进行分析。评价脑功能网络的定量指标(聚类系数、特征路径长度,全局效率,程度分布,和小世界)。统计学分析包括方差分析和相关性分析。

在患者和志愿者间,聚类系数、特征路径长度、程度分布和小世界参数具有统计学差异(P < 0.05)。MMSE评分与特征路径长度具有负性相关,Hb1Ac与小世界呈负性相关。除了Hb1Ac,MMSE、糖尿病病程、糖尿病足筛查、空腹血糖、胰岛素、Homa-β、 Homa-IR、 ISI、DR分析、年龄与特定脑区程度分布具有相关性。

本研究表明,糖尿病视网膜病变患者脑功能网络发生改变,尤其是在视皮层和认知功能区域,从而可能会 影响弱视和认知能力。此外,长期或一过性临床因素也会影响脑功能网络。

原始出处:

Dai H, Zhang Y, Lai L, et al,Brain functional networks: correlation analysis with clinical indexes in patients with diabetic retinopathy. 2017.DOI: 10.1007/s00234-017-1900-5

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    2017-09-14 zutt
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    2017-09-13 suibian2007bbb

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