Oral Dis:补充维生素D对牙周炎患者局部和全身炎症指标的影响

2020-06-17 MedSci原创 MedSci原创

维生素D缺乏/不足是一个世界性的公共健康问题,与包括牙周炎在内的众多炎症性疾病有关。越来越多的人支持足够的维生素D水平在整体健康中的作用。皮肤颜色较深的人群,维生素D缺乏/不足和牙周炎的发病率较高。这

维生素D缺乏/不足是一个世界性的公共健康问题,与包括牙周炎在内的众多炎症性疾病有关。越来越多的人支持足够的维生素D水平在整体健康中的作用。皮肤颜色较深的人群,维生素D缺乏/不足和牙周炎的发病率较高。这项小型试验研究的目的是调查12周25(OH)D维生素D补充剂(VDS)对黑皮肤、牙周炎患者全身炎症介质的影响。

 

将共23例中度至重度牙周炎患者随机分配到维生素D组或安慰剂组,并接受单次集中洗牙和根部规划,以引起全身炎症反应。

 

结果显示,维生素D补充使血清25(OH)D水平比基线水平增加约2倍;此外,VDS组的外周血CD3和CD3+CD8+细胞毒性T淋巴细胞(CTL)数量减少,促炎性唾液细胞因子减少。相比之下,VDS组的全血PBMCs中自噬相关蛋白和其他对抗微生物自噬至关重要的蛋白水平更高。

 

总之,VDS对减轻全身炎症和促进诱导与抗微生物功能相关的自噬相关蛋白有多重好处。

 

原始出处:

 

Mohamed M MeghilLance Hutchens, et al., The Influence of Vitamin D Supplementation on Local and Systemic Inflammatory Markers in Periodontitis Patients: A Pilot Study. Oral Dis. 2019 Jul;25(5):1403-1413.

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    2021-05-22 cmj8wellington
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    2021-04-22 小几洁
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    2020-06-19 chg122
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    2020-06-17 lovetcm

    #维生素D#常规应该补充

    0

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