Neurobiol Aging:光生物调节减少老年小鼠基底神经节中的胶质细胞增生

2018-03-24 cuiguizhong MedSci原创

澳大利亚悉尼大学解剖学系的El Massri N和伦敦大学学院眼科研究所的Weinrich TW近日在Neurobiol Aging杂志上发表了一篇重要的文章,探讨了长期光生物调节(PBM)对老年小鼠纹状体中胶质细胞和神经元的影响。

澳大利亚悉尼大学解剖学系的El Massri N和伦敦大学学院眼科研究所的Weinrich TW近日在Neurobiol Aging杂志上发表了一篇重要的文章,探讨了长期光生物调节(PBM)对老年小鼠纹状体中胶质细胞和神经元的影响。

他们使用5个月龄的小鼠,每天用PBM(670nm)预处理20分钟,一直持续8个月到12月龄。他们设有2个对照组,分别为3个月大小鼠和12个月大小鼠,这些小鼠没有进行处理。将脑组织进行甲醛固定,并用各种胶质细胞和神经元分子标记物进行免疫组织化学处理。

分析结果,发现老年小鼠经PBM处理后,纹状体中星形胶质细胞和小胶质细胞数量明显减少。与对照组相比,2种纹状体中间神经元的数量,以及纹状体多巴胺能神经元的密度,在处理后保持不变。

总之,他们的研究结果表明,通过减少胶质细胞数量,长期光生物调节(PBM)对衰老的纹状体有益。此外,这种处理对纹状体中的神经元没有任何有害的作用。

原文出处:

El Massri, N., et al., Photobiomodulation reduces gliosis in the basal ganglia of aged mice. Neurobiol Aging, 2018. 66: p. 131-137.

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    2018-08-02 sunylz
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    2018-03-24 清风拂面

    谢谢分享学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1917986, encodeId=9a4e191e98673, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Aug 02 06:42:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040667, encodeId=ec04204066eb6, content=<a href='/topic/show?id=04fe42058e0' target=_blank style='color:#2F92EE;'>#基底神经节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42058, encryptionId=04fe42058e0, topicName=基底神经节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu May 03 16:42:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767397, encodeId=c65a1e67397ba, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sun Apr 08 06:42:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389192, encodeId=814c13891928e, content=<a href='/topic/show?id=acf3840e459' target=_blank style='color:#2F92EE;'>#胶质细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84074, encryptionId=acf3840e459, topicName=胶质细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/DC48AC6B5FFD609EED5594C15A97B420/100, createdBy=57dc2500034, createdName=ms1692212821629096, createdTime=Mon Mar 26 13:42:00 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299369, encodeId=515c29936956, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Mar 24 23:40:12 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299354, encodeId=5cc429935481, content=客观性.公正性.讲得很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Mar 24 22:56:35 CST 2018, time=2018-03-24, status=1, ipAttribution=)]
    2018-03-24 虈亣靌

    客观性.公正性.讲得很不错

    0

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