CMI：养老院居民全剂量接种Comirnaty®COVID-19疫苗后对SARS-CoV-2的免疫反应

2021-10-11 从医路漫漫 MedSci原创

老年人优先接种SARS-CoV-2疫苗，因为他们有患严重COVID-19的风险增加。在养老院SARS-CoV-2信使RNA(mRNA)疫苗，导致了SARS-CoV-2感染率，尤其是COVID-19感染

背景：老年人优先接种SARS-CoV-2疫苗，因为他们有患严重COVID-19的风险增加。在养老院SARS-CoV-2信使RNA(mRNA)疫苗，导致了SARS-CoV-2感染率，尤其是COVID-19感染率的大幅下降。虽然这一效应主要是由居民和工作人员的疫苗覆盖率来解释的，但严格的非药物感染控制措施也有助于预防85名未接种疫苗的居民和那些对疫苗的非最佳或检测不到SARS-CoV-2特异性免疫反应的人的感染。

目前关于SARS-CoV-2 mRNA疫苗在伴有合并症和衰弱的老年人中的免疫原性的信息有限。Comirnaty®COVID-19疫苗(辉瑞- bnt162b2) I期试验的数据表明，老年人的抗体反应低于年轻人。到2021年3月，瓦伦西亚社区(VC)建立了一项COVID-19疫苗研究计划(ProVaVac)，该计划的任务之一是评估疗养院居民中SARS-CoV-2 mRNA疫苗的免疫原性。在此报告这次调查的结果。

目的:本研究旨在检测两剂Comirnaty®COVID-19疫苗在养老院老年人中的SARS-CoV-2免疫应答。

方法:前瞻性队列研究的代表性样本来自瓦伦西亚养老院(n=881;男性:271名，女性610名;中位年龄为86岁)，采用随机单阶段整群抽样方法。侧流免疫层析成像装置(LFIC)(现场COVID-19 IgG/IgM快速检测;采用CTK BIOTECH, Poway, CA, USA)作为检测全血中SARS-CoV-2-Spike(S)特异性抗体的一线试验。对LFIC阴性的居民进行静脉穿刺，并通过罗氏Elecsys®Anti-SARS-CoV-2 S(罗氏诊断公司，Pleasanton, CA, USA)检测SARS-CoV-2反应抗体和T细胞的存在，以及LIAISON®SARS-CoV-2 TrimericS IgG (DiasorinS.p.)检测。A, Saluggia，意大利)，并分别采用流式细胞术检测。

结果:在疫苗完全接种后99天(范围17-125天)内，康复者和养老院居民SARS-CoV-2- s抗体检出率分别为99.6%(283/289)和98.3%(587/597)。五分之三缺乏SARS-CoV-2-S抗体的居民有可检测到的s反应性CD8+和/或CD4+ T细胞。检测到SARS-CoV-2抗体的50/50和40/50参与者也分别有SARS-CoV-2- s反应性IFN-γ产生CD4+和CD8+ T细胞。

表1 在SARS-CoV-2-naïve或康复疗养院居民全剂量接种Comirnaty®后，通过横向流动免疫层析测定SARS-CoV-2 IgG应答

表2 流式细胞术检测全剂量Comirnaty®疫苗接种后可检测到SARS-CoV-2-S抗体的养老院居民的SARS-CoV-2-S反应性T细胞

图根据罗氏Elecsys®抗sars - cov -2-S免疫分析定量的sars - cov -2-S反应抗体水平，侧流免疫层析(LFIC) IgG谱线强度。线的强度是用一个4级的量表进行视觉评分的。从右到左0，不可检测;1+，弱阳性(测试带强度低于对照带强度);2+，阳性结果(测试带强度等于控制线);3+，强阳性结果(测试带强度大于控制线)。

结论：Comirnaty®新冠肺炎疫苗对疗养院居民具有很强的免疫原性。

原文出处：

Albert E, Burgos JS, Peiró S,et al,Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents.Clin Microbiol Infect 2021 Oct 04

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2021-12-04 liye789132251

#Nat#

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2022-05-17 smallant2002

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2022-06-22 hukaixun

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2021-10-10 cnxcy

#免疫反应#

0 0
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2021-10-10 Homburg

#miRNA#

44 0
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2021-10-10 小刀医生

#SARS#

20 0
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2021-10-10 tulenzi

#养老院#

29 0

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