Gastroenterology:肝硬化人群耐药菌感染风险评估

2018-12-25 zhangfan MedSci原创

研究发现,肝硬化患者耐药菌感染风险增加,特别是印度患者的耐药菌感染率最高

对于肝硬化患者中,细菌感染十分常见,在某些情况下可能危及生命。近日研究人员开展一项多中心前瞻性洲际研究,以评估肝硬化患者中细菌和真菌感染的发生率和结果。

来自欧洲、亚洲以及南北美洲的46个医疗中心参与本次研究,总计包含1302名患者,研究从2015年10月持续至2016年9月,考察患者门诊及住院期间的人口学、临床、微生物学和治疗数据,随访至患者死亡、肝移植或出院。

肝硬化人群多药耐药菌(MDR)的全球流行率为34%,存在显著的地域差异,其中亚洲的耐药率最高。MDR独立的风险因素包括:亚洲特别是印度人群、住院前3个月使用抗生素以及感染部位。因MDR导致的感染会增加症状消除的困难程度、增加休克和器官衰竭风险,导致住院死亡率更高增加。研究发现,给予患者足够的经验性抗生素治疗可改善症状,提高生存率。

研究发现,肝硬化患者耐药菌感染风险增加,特别是印度患者的耐药菌感染率最高。

原始出处:

Salvatore Piano et al. Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide. Gastroenterology. December 21, 2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2019-07-08 许安

    #GAS#

    0

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    2019-02-25 jktdtl
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    2019-12-02 hxq78328
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level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418681, encodeId=c4831418681eb, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356452, encodeId=8deb35645243, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=209, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:13 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356451, encodeId=165935645167, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:09 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2019-01-09 一个字-牛

    学习了谢谢分享

    0

  5. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=209, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:13 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356451, encodeId=165935645167, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:09 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2019-10-03 柳叶一刀

    #AST#

    0

  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-27 xiaoshitou
  8. [GetPortalCommentsPageByObjectIdResponse(id=2072407, encodeId=9c1520e240704, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Jul 08 19:45:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064578, encodeId=e6b520645e85a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, 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level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418681, encodeId=c4831418681eb, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356452, encodeId=8deb35645243, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=209, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:13 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356451, encodeId=165935645167, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:09 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-26 Y—xianghai

    学习了新知识

    0

  9. 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level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418681, encodeId=c4831418681eb, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Dec 27 01:45:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356452, encodeId=8deb35645243, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=209, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:13 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356451, encodeId=165935645167, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:09 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-26 Y—xianghai

    学习了长知识

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=356450, encodeId=fe7b356450fe, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 26 08:03:05 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-26 Y—xianghai

    学习了新知识

    0

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