Cancer:前列腺癌根治术后长期存活者对肿瘤复发和疾病进展的恐惧:一项纵向研究

2021-08-22 AlexYang MedSci原创

前列腺癌(PCa)是美国和欧洲男性中第二大最常诊断的癌症。高存活率使PCa患者的生存成为一种长期的过程,因而改善生活质量(QOL)和心理健康是诊断和治疗后护理的基本考虑。最近的研究表明,

前列腺癌(PCa)是美国和欧洲男性中第二大最常诊断的癌症。高存活率使PCa患者的生存成为一种长期的过程,因而改善生活质量(QOL)和心理健康是诊断和治疗后护理的基本考虑。最近的研究表明,对癌症复发恐惧(FCR)或疾病进展的焦虑是癌症幸存者最常认可未满足的需求和关切之一,而且对QOL具有临床显著影响

尽管对癌症复发(FCR)或疾病进展的恐惧是癌症幸存者最认可的未满足的需求和关注之一,但对长期幸存者中FCR的研究却很缺乏。近期,有研究人员纵向评估了长期前列腺癌(PCa)幸存者中FCR的发生率和预测因素

研究队列包括了来自德国多中心家族性前列腺癌数据库的2417名幸存者,他们在前列腺根治术后平均7年(2010年为T1)和9年后的随访中(2019年为T2)完成了恐惧进展问卷-短表。分层多变量逻辑回归法用来评估随访时FCR的预测因素。

初次评估的平均年龄为69.5岁(标准差为5.9岁);在初次评估(T1)和随访(T2)时,分别有6.5%和8.4%的患者报告有临床FCR。在控制并发关系的多变量分析中,9年后FCR的纵向预测因素包括较低的教育水平(几率比[OR],4.35;95%置信区间[CI],2.33-8.33),根治性前列腺切除术后的年数(OR,1. 10;95%CI,1.03-1.18),生化复发(OR,1.67;95%CI,1.02-2.72),目前没有辅助治疗(OR,2.38;95%CI,1.19-4.76),FCR(OR,10.75;95%CI,6.18-18.72)和焦虑(OR,1.35;95%CI,1.06-1.72)。

2010年至2019年根据对癌症复发的恐惧情况的患者分布

综上所述,FCR对某些PCa幸存者来说仍然是一个负担,甚至在他们被诊断和治疗多年后仍然存在。医疗护理专业人员应对FCR进行检测并识别有风险的病人,从而提供适当的社会心理护理,避免FCR引起生活质量和心理健康的损害。

原始出处:

Valentin H Meissner, Lisa Olze , Stefan Schiele et al. Fear of cancer recurrence and disease progression in long-term prostate cancer survivors after radical prostatectomy: A longitudinal study. Cancer. Aug 2021

 

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    2021-08-24 jeanqiuqiu
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    2021-08-22 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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