Gut: 粪菌移植有益于肥胖T2DM患者

2021-04-07 MedSci原创 MedSci原创

重复FMTs可提高肥胖T2DM患者的微生物群植入水平和持续时间。生活方式干预与FMT相结合可使受者的微生物群发生更有利的变化,并改善血脂和肝脏硬度。

粪便微生物移植(FMT)代谢综合征患者微生物移植的影响尚不明确。Siew C Ng等研究了FMT与生活方式改变相结合是否能增强肥胖合并2糖尿病(T2DM)患者有利微生物群的植入。研究成果发表在GUT杂志。

这项双盲、随机、安慰剂对照试验中,61名肥胖T2DM患者被随机分配到三个平行组:FMT +生活方式干预(LSI),单独FMT,或假移植+ LSI,每4周进行一次,持续到第12周。FMT溶液是由6名健康的瘦捐献者配制的。分别在基线、第4周、第16周和第24周进行粪便宏基因组测序。主要结果是受试者在第24周从供体获得≥20%微生物群的比例。

粪便微生物群分析显示FMT使肥胖2型糖尿病患者持续植入瘦相关菌群。(A) W24时瘦相关菌群≥20%的受试者比例。(B) W4W16W24处瘦相关微生物群百分比的箱线图。采用Mann-Whitney U检验和Bonferroni校正计算治疗组间的显著性。

粪便微生物组分析显示,在生活方式干预下,FMT比假移植带来更有利的改变。(A)三个处理干预后,以Chao1丰富度和Shannon多样性指数为代表的微生物区系丰富度和多样性的变化。治疗组内的显著性通过Wilcoxon符号秩检验计算。(B) W4W16W24时基线和处理后微生物群组成的欧氏距离变化。采用Mann-Whitney U检验和Bonferroni校正计算治疗组间的显著性。(C)各处理组经LEfSe干预后显著改变的细菌种类的LDA效应大小(LDA>2,调整后的p<0.05)

 

在第24周,FMT + LSI组、FMT单独组和假移植+ LSI组获得瘦相关菌群≥20%的受试者比例分别为100%88.2%22% (p<0.0001)重复FMTs显著增加了瘦相关菌群的植入(p<0.05)。添加或不添加LSIFMT增加了丁酸盐产生菌。与单独使用FMT相比,LSIFMT联合使用导致双歧杆菌和乳酸杆菌增加(p<0.05)FMT + LSI24周时总脂蛋白胆固醇、低密度脂蛋白胆固醇及肝脏硬度均较基线降低(p<0.05)

综上所述,重复FMTs可提高肥胖T2DM患者的微生物群植入水平和持续时间。生活方式干预与FMT相结合可使受者的微生物群发生更有利的变化,并改善血脂和肝脏硬度

原文出处

Ng SC, Xu Z, Mak JWY, et al. Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial [published online ahead of print, 2021 Mar 30]. Gut. 2021;gutjnl-2020-323617. doi:10.1136/gutjnl-2020-323617

 

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    2021-04-30 MedSciZeng

    #Gut#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

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    2021-04-08 易水河

    肠道菌群要保护好

    0

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    2021-04-08 ms5000000291904860

    点赞🤙🤙🤙

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肥胖/超重与儿童更高的过敏性鼻炎(AR)风险有关。

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减肥手术可能与患肥胖相关癌症的风险显着降低有关

JAHA:青年成人健身和肥胖与中年期右心室功能和肺动脉收缩压之间的纵向关联

成年后较高的CRF和随时间推移CRF下降程度较少均与较好的RV收缩功能相关。较高的基线BMI和与年龄相关的BMI增加均与中年PASP升高显著相关。

Circulation:伴有肥胖的心血管疾病患者减肥手术与心血管结局的关系

在伴有心血管疾病和肥胖患者中,减肥手术与较低的MACE发生率相关。但这些结果需要大规模随机试验进一步验证。

JCEM:血清促甲状腺激素与肥胖之间的因果关系

将fT3一起考虑,TSH可以通过基因驱动BMI的增加而显著升高。