Hypertension:伴有白蛋白尿的高血压成人中使用ACE抑制剂或ARB的趋势

2020-11-16 MedSci原创 MedSci原创

ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。

自2003年以来,美国高血压指南已建议伴有白蛋白尿(尿白蛋白/肌酐比≥300 mg/g)的高血压患者将血管紧张素转换酶(ACE)抑制剂或血管紧张素受体阻滞剂(ARB)作为一线降压治疗药物。

为了评估指南推荐的ACE抑制剂/ARB使用全国趋势,近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员分析了参加2001年至2018年美国国家健康和营养调查的高血压患者(由自我报告的高血压,收缩压≥140mmHg或舒张压≥90mmHg,或使用降压药来进行定义)。

在20538名成年人中,白蛋白尿≥300 mg/g的患病率在2001年至2006年期间为2.8%,在2007年至2012年期间为2.8%,在2013年至2018年为3.2%。在白蛋白尿≥300 mg/g的人中,从2001年到2018年期间,在伴有糖尿病或不伴有糖尿病的患者中观察到接受ACE抑制剂/ARB治疗的比例有不一致的趋势。2013年至2018年,在白蛋白尿≥300 mg/g且伴有糖尿病的成年人中ACE抑制剂/ARB使用率为55.3%(95%CI为46.8%–63.6%),在不伴有糖尿病的患者中为33.4%(95%CI为23.1%–45.5%)。根据美国人群统计,目前估计有160万伴有白蛋白尿≥300mg/g的成年人未接受ACE抑制剂/ARB治疗,其中近一半没有糖尿病。

由此可见,ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。

原始出处:

Chi D. Chu.et al.Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use Among Hypertensive US Adults With Albuminuria.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16281

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encodeId=cf9190011e2c, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Wed Nov 18 10:13:05 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2021-08-12 shanyongle
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    2021-10-07 ms8000002121144240

    ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,

    0

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encodeId=cf9190011e2c, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Wed Nov 18 10:13:05 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2021-01-21 jklm09
  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852543, encodeId=ab77185254398, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Jan 21 13:44:26 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039225, encodeId=14182039225ee, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=cf9190011e2c, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Wed Nov 18 10:13:05 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1656039, encodeId=830a1656039c7, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Aug 12 15:44:26 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058264, encodeId=17cf105826492, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=794f5626899, createdName=ms8000002121144240, createdTime=Thu Oct 07 09:41:27 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852543, encodeId=ab77185254398, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Jan 21 13:44:26 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039225, encodeId=14182039225ee, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377113, encodeId=3dfd13e7113d1, content=<a href='/topic/show?id=ae99e1769f9' target=_blank style='color:#2F92EE;'>#白蛋白尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71769, encryptionId=ae99e1769f9, topicName=白蛋白尿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501502, encodeId=03a5150150241, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587539, encodeId=8265158e5392e, content=<a href='/topic/show?id=d1201843d5' target=_blank style='color:#2F92EE;'>#ACE抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1843, encryptionId=d1201843d5, topicName=ACE抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fca217484051, createdName=huanbaofeng, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900117, encodeId=cf9190011e2c, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Wed Nov 18 10:13:05 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2021-06-02 feather89
  6. [GetPortalCommentsPageByObjectIdResponse(id=1656039, encodeId=830a1656039c7, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Aug 12 15:44:26 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058264, encodeId=17cf105826492, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=794f5626899, createdName=ms8000002121144240, createdTime=Thu Oct 07 09:41:27 CST 2021, time=2021-10-07, 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objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587539, encodeId=8265158e5392e, content=<a href='/topic/show?id=d1201843d5' target=_blank style='color:#2F92EE;'>#ACE抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1843, encryptionId=d1201843d5, topicName=ACE抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fca217484051, createdName=huanbaofeng, createdTime=Wed Nov 18 13:44:26 CST 2020, time=2020-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900117, encodeId=cf9190011e2c, content=ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Wed Nov 18 10:13:05 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2020-11-18 珙桐
  7. 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    2020-11-18 咻凡

    ACE抑制剂/ARB使用率较低代表伴有白蛋白尿的高血压成人预防保健服务中的显著差距,该差距并未随着时间的推移发生实质性改善。

    0

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