BMJ:产妇早产导致女性死亡的重要风险因素

2020-08-22 MedSci原创 MedSci原创

早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著

近日研究人员在一个以人群为基础的女性队列中,考察了孕妇早产相关的长期死亡风险。

研究在瑞典开展,1973-2015年2189477名单胎分娩女性参与,从全国死亡记录中确定截至2016年的所有原因和特定原因死亡数据,通过Cox回归用于计算危险比,同时评估了遗传和环境因素的潜在影响。

在5070万人-年的随访中,76535(3.5%)名女性参与者死亡(平均死亡年龄为57.6岁)。在分娩后10年内,孕妇早产(<37周)相关的所有原因死亡率的调整风险比为1.73,当进一步分层时,与足月分娩(39-41周)相比,极早产(22-27周)产妇全因死亡率的调整风险比为2.20,极早产(28-33周)为2.28,晚期早产(34-36周)为1.52,早期足月分娩(37-38周)为1.19。上述风险在较长的随访期间仍显著增加:对于早产和足月产产妇,分娩后10-19年,全因死亡的调整后风险比为1.45;分娩后20-44年,调整后的风险比为1.37。

这些发现似乎并不能归因于家庭内部的共同遗传或环境因素,可确定的因素包括血管、呼吸系统疾病、糖尿病和癌症。

研究发现,早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著。

原始出处:

Casey Crump et al. Preterm delivery and long term mortality in women: national cohort and co-sibling study. BMJ,August 19, 2020.

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    2021-06-08 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1849082, encodeId=da46184908292, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jun 08 03:28:21 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812491, encodeId=f27081249166, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:21 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811988, encodeId=103c8119887a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81675412539, createdName=ms2000000583115957, createdTime=Sat Aug 22 09:48:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811986, encodeId=3e5181198671, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKM5opSMdO81JdZ2M7o9npdRIaB2cqAxzEC1Q9Hqht0VPJlxnQMx1IhAYibaFXYKg7emtfR6hkpZtA/132, createdBy=96432493356, createdName=yhthzx, createdTime=Sat Aug 22 09:46:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811976, encodeId=3eea8119e6ab, content=早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Aug 22 09:38:34 CST 2020, time=2020-08-22, status=1, ipAttribution=)]
    2020-08-23 红豆豆豆豆

    不错 点赞收藏学习起来

    0

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    2020-08-22 ms2000000583115957

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1849082, encodeId=da46184908292, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jun 08 03:28:21 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812491, encodeId=f27081249166, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:21 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811988, encodeId=103c8119887a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81675412539, createdName=ms2000000583115957, createdTime=Sat Aug 22 09:48:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811986, encodeId=3e5181198671, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKM5opSMdO81JdZ2M7o9npdRIaB2cqAxzEC1Q9Hqht0VPJlxnQMx1IhAYibaFXYKg7emtfR6hkpZtA/132, createdBy=96432493356, createdName=yhthzx, createdTime=Sat Aug 22 09:46:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811976, encodeId=3eea8119e6ab, content=早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Aug 22 09:38:34 CST 2020, time=2020-08-22, status=1, ipAttribution=)]
    2020-08-22 yhthzx

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1849082, encodeId=da46184908292, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jun 08 03:28:21 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812491, encodeId=f27081249166, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:21 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811988, encodeId=103c8119887a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81675412539, createdName=ms2000000583115957, createdTime=Sat Aug 22 09:48:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811986, encodeId=3e5181198671, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKM5opSMdO81JdZ2M7o9npdRIaB2cqAxzEC1Q9Hqht0VPJlxnQMx1IhAYibaFXYKg7emtfR6hkpZtA/132, createdBy=96432493356, createdName=yhthzx, createdTime=Sat Aug 22 09:46:07 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811976, encodeId=3eea8119e6ab, content=早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Aug 22 09:38:34 CST 2020, time=2020-08-22, status=1, ipAttribution=)]
    2020-08-22 言西早

    早产孕妇的过早死亡风险相对于足月产孕妇显著增加,这一风险在分娩后40年仍较为显著。

    0

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