Crit Care Med:从急诊到ICU时间与住院死亡率有关

2019-08-12 xing.T MedSci原创

由此可见,从急诊到ICU的时间延长(>2.4小时)与ICU入院后住院死亡率增加有关,主要归因于急性生理学和慢性健康评估IV概率较高的患者。该研究提供的证据表明重症患者迅速送入ICU可能会降低住院死亡率。

延长急诊室到ICU的等待时间可能会延误重症监护治疗,这可能会对患者的预后产生负面影响。近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,这项研究的目的是调查从急诊到ICU的时间是否与住院死亡率相关。

研究人员使用荷兰质量登记处国家重症监护评估的数据进行了一项回顾性观察性队列研究。在2009年至2016年期间,研究人员纳入了六所大学医院的从急诊室直接入住ICU的成年患者,并使用Logistic回归模型调查了从急诊到ICU时间与死亡率的原始和调整后(疾病严重程度;急性生理学和慢性健康评估IV概率)比值比。此外,研究人员评估了急性生理学和慢性健康评估IV概率是否改变了从急诊到ICU时间对死亡率的影响。次要结局是ICU、30天和90天死亡率。

该研究共纳入了14788名患者。从急诊科到ICU时间的中位数为2.0小时(四分位间距为1.3-3.3小时)。从急诊到ICU的时间与调整后的住院死亡率相关(p<0.002),特别是在急性生理学和慢性健康评估IV概率和从急诊到ICU时间最高五分位数的患者中:比值比为1.29; 95%CI为1.02-1.64(2.4-3.7小时)和比值比为1.54; 95%CI为1.11-2.14(>3.7小时),均与对照组(<1.2小时)进行比较。对于30天和90天的死亡率,研究人员得到了类似的结果。然而,从急诊到ICU时间与调整的ICU死亡率无关(p=0.20)。

由此可见,从急诊到ICU的时间延长(>2.4小时)与ICU入院后住院死亡率增加有关,主要归因于急性生理学和慢性健康评估IV概率较高的患者。该研究提供的证据表明重症患者迅速送入ICU可能会降低住院死亡率。 

原始出处:

Groenland, Carline N. L. et al.Emergency Department to ICU Time Is Associated With Hospital Mortality A Registry Analysis of 14,788 Patients From Six University Hospitals in the Netherlands.critical care medicine.2019. https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Emergency_Department_to_ICU_Time_Is_Associated.95865.aspx

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