Diabetic Med:糖尿病老年人中抑郁症状的患病率和相关性:社区动脉粥样硬化风险(ARIC)研究

2018-10-23 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于糖尿病老年人中抑郁症状的患病率和相关性:社区动脉粥样硬化风险(ARIC)研究。研究目的是记录老年人血糖谱中当前抑郁症状和抑郁史的患病率,并检查健康状况和医疗保健满意度,获取和利用的衡量标准是否可解释糖尿病状态下当前抑郁症状患病率的差异。 研究人员对参加2011 - 2013年动脉粥样硬化社区风险(ARIC)研究的6226名67-9

近日,国际杂志 《Diabetic Med》上在线发表一项关于糖尿病老年人中抑郁症状的患病率和相关性:社区动脉粥样硬化风险(ARIC)研究。研究目的是记录老年人血糖谱中当前抑郁症状和抑郁史的患病率,并检查健康状况和医疗保健满意度,获取和利用的衡量标准是否可解释糖尿病状态下当前抑郁症状患病率的差异。

研究人员对参加2011 - 2013年动脉粥样硬化社区风险(ARIC)研究的622667-90岁参与者进行了横断面研究。糖尿病基于自我报告,药物使用和HbA 1c。目前的抑郁症状使用流行病学研究中心抑郁症11项问卷来定义,并通过自我报告评估抑郁症的病史。与其他人相比,研究人员检查了肥胖,血管疾病史,高血压,肾脏疾病,认知功能和自我报告的健康状况。使用年龄,种族和性别校正的泊松回归估计患病率和患病率。

目前抑郁症状患病率在非糖尿病患者中为5.4%,在糖尿病患者中为11.0%(患病率2.04,95CI 1.60,2.48; 非糖尿病患者抑郁症史患病率为11%,糖尿病患者为17.7%(患病率1.61,95CI 1.28,1.95)。与其他人相比,当前抑郁症状关联交密切的是有抑郁史(流行率3.86,95CI 3.05,4.90),和健康状况不佳(患病率3.88,95CI 2.93,5.15)。未发现相关变量与血糖类别的抑郁症状有显著差异(P为相互作用> 0.10)。

在老年人中,糖尿病患者目前的抑郁症状是没有糖尿病的人的两倍。健康状况和医疗保健措施并未解释糖尿病患者与非糖尿病患者之间抑郁症状的差异。

原始出处:

A. M. Rawlings A. R. Sharrett, S. H. Goldenet al. Prevalence and correlates of depressive symptoms in older adults across the glycaemic spectrum: the Atherosclerosis Risk in Communities (ARIC) study

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    2018-10-23 jyzxjiangqin

    糖尿病患者的治疗。

    0

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在线发表于《EBioMedicine》杂志上的一项研究表明,抗-丙二醛IgM抗体的循环水平较低时与发生冠心病(CHD)相关。

BMJ:他汀类药物可显著降低75-84岁老年糖尿病患者动脉粥样硬化风险

研究认为,他汀类对75-84糖尿病患者动脉粥样硬化性心血管疾病的保护作用最为显著,但对于非糖尿病患者以及85岁以上老年人群的效果不明显

Arthritis Rheumatol:银屑病关节炎中最小的疾病活动性能否预防亚临床动脉粥样硬化的进展

这项研究结果支持这样的建议:一旦达到MDA,理想情况下应维持较长时间,以防止PsA患者颈动脉粥样硬化和动脉硬化的进展。

Circulation:胆固醇流出通路可抑制炎症小体激活、坏死和动脉粥样硬化

CANTOS试验(研究康纳单抗抗炎性血栓预后)显示,白介素(IL)-1β的拮抗剂可减轻有心肌梗死病史患者的冠心病,同时可减少全身性炎症,提示调控IL-1β分泌的信号通路可增加心血管风险。胆固醇积累时,骨髓细胞可通过NLRP3炎症小体产生IL-1β和IL-18,但NLRP3炎症小体激活与动脉粥样硬化形成的关联尚不明确。胆固醇转运体ATP结合盒A1/G1(ABCA1/G1)介导胆固醇形成高密度脂蛋白,

Circulation:卵磷脂:胆固醇酰基转移酶(LCAT)完全缺陷或部分缺陷,对动脉粥样硬化存在迥然不同的影响

卵磷脂:胆固醇酰基转移酶(LCAT)是血浆中唯一酯化胆固醇的酶。据报道,由LCAT突变导致的鱼眼病(FED)或家族性LCAT缺陷(FLD)分别与颈动脉粥样硬化增加和减少相关。LCAT究竟在动脉粥样硬化过程中发挥怎样的作用?上述差异是否是由仅载脂蛋白AI(FED)上的胆固醇酯化或包含载脂蛋白AI和载脂蛋白B两者的脂蛋白(FLD)上的胆固醇酯化所造成的?现Federico Oldoni等人对此进行研究