JAMA Neurol:抽动障碍人群代谢及心血管疾病风险研究

2019-01-21 zhangfan MedSci原创

研究发现,抽动障碍或慢性抽动障碍人群代谢以及心血管疾病风险显著增加,儿童、注意缺陷以及多动障碍患者是主要受影响人群

近日研究人员考察了抽动障碍(TS)或慢性抽动障碍(CTD)与代谢和血管疾病风险之间的关系。

本次研究基于1973-2013年间瑞典纵向人口队列研究数据,研究的主要终点为TS或CTD患者中肥胖、血脂异常、高血压、2型糖尿病血管疾病(包括缺血性心脏病、心律失常、脑血管病、短暂性缺血发作和动脉硬化)的发病风险。

14045026人参与,其中7804人诊断为TS或CTD,患者中男性5964人(76.4%)。研究发现,TS以及CTD患者任何代谢疾病以及心血管疾病风险较一般人群增加(HR=1.99),TS以及CTD患者较其正常亲属的风险也上升(HR=1.37)。值得一提,TS以及CTD人群,肥胖(2.76)、2型糖尿病(1.67)以及循环系统疾病(1.76)风险显著提高。研究发现,儿童、注意缺陷以及多动障碍患者是受影响最为显著的人群,排除上述人群后,其他患者的疾病风险不显著。与不服用抗精神病药的TS或CTD患者相比,长期抗精神病治疗(>1年)患者发生代谢和心血管疾病的风险明显降低。

研究发现,抽动障碍或慢性抽动障碍人群代谢以及心血管疾病风险显著增加,儿童、注意缺陷以及多动障碍患者是主要受影响人群。

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    2019-09-24 yinhl1978
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    2019-01-21 SCI我的梦

    冒昧问一句,流行病学上将OR或RR大于2认为有意义。这个研究说的HR仅仅才1点几这有多大意义?

    0

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    2019-01-21 明月清辉

    谢谢分享,学习了

    0

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