Brit J Surg:大肠癌术后血培养与长期肿瘤学结局之间的关联

2019-11-26 xing.T MedSci原创

由此可见,结直肠癌手术后30天内需要进行血培养的临床怀疑感染与患者较差的肿瘤学结局有关。

大肠癌患者的全身性炎症可能与复发风险增加有关。近日,外科疾病领域权威杂志British Journal of Surgery上发表了一篇研究文章,这项研究调查了在大肠癌手术后30天内进行血培养的临床可疑感染是否与长期肿瘤学结局有关。

这项基于登记处的全国队列研究纳入了所有接受手术治疗且有治愈意图的丹麦居民。这些居民在2003年1月至2013年12月期间发生大肠癌。手术后180天内出现复发或死亡的患者不包括在内。研究人员使用针对相关临床混杂因素调整的Cox回归模型分析了在初次手术后30天内采血进行的血液培养与总生存、无病生存和无复发生存之间的关联,调整的因素包括人口统计学数据、癌症分期、合并症、输血情况、术后并发症及辅助化疗。

该研究共纳入了21349例患者,其中3390例(15.9%)患者在术后30天内进行了血培养。中位随访时间为5.6年,进行过血液培养的患者全因死亡风险增加(风险比(HR)为1.27,95%CI为1.20至1.35;P<0.001),无病生存期较差(HR为1.22、1.16至1.29;P<0.001)和复发风险更高(HR为1.15、1.07至1.23;P<0.001)。

由此可见,直肠癌手术后30天内需要进行血培养的临床怀疑感染与患者较差的肿瘤学结局有关。 

原始出处:

S. K. Watt.et al.Associations between blood cultures after surgery for colorectal cancer and long‐term oncological outcomes. British Journal of Surgery.2019.https://doi.org/10.1002/bjs.11372

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    2019-11-28 1de7a66em30(暂无匿称)

    学习了,思路很好

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    2019-11-27 14794e5bm67(暂无昵称)

    研究很前沿,受益良多

    0

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