JAHA:肾小球疾病患儿心血管疾病危险因素的患病情况

2019-07-09 xing.T MedSci原创

由此可见,原发性肾小球疾病的儿童表现出高频率的可改变的心血管危险因素,特别是未治疗的血脂异常。应定期测量血脂,以更好地确定该群体血脂异常的负担。目前筛查和治疗心血管危险因素的方法并不统一,突出了对基于证据的疾病特异性指南的需求。

血管疾病是慢性肾病患儿发病率和死亡率的主要原因。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员试图明确肾小球疾病患儿心血管危险因素的患病率,并描述目前关于危险因素识别和管理临床实践。

761名年龄在0至17岁的儿童,活检证实为原发性肾小球疾病(微小病变、局灶性节段性肾小球硬化、膜性肾病和IgA肾病/血管炎),这些患者均来自前瞻性治疗性肾小球肾病网络研究中,在肾小球疾病诊断时的中位数为16个月。在入组时确定传统(高血压、高胆固醇血症和肥胖)和新型(蛋白尿、早产和被动烟雾暴露)心血管危险因素的患病率,并比较肾小球疾病亚型。在肾小球疾病、类固醇暴露和缓解状态亚型中,比较了血脂异常的筛查频率和降脂或抗高血压药物的处方情况。

与一般人群相比,所有传统危险因素更为频繁;在这些筛查者中,21%患有高血压,51%患有超重或肥胖,71%患有血脂异常。招募时未达到缓解的儿童更容易患高血压和高胆固醇血症。14%的高血压儿童未接受抗高血压治疗。只有49%的患者接受了血脂异常的筛查,只有9%的血脂异常患者接受了降脂药物治疗。

由此可见,原发性肾小球疾病的儿童表现出高频率的可改变的心血管危险因素,特别是未治疗的血脂异常。应定期测量血脂,以更好地确定该群体血脂异常的负担。目前筛查和治疗心血管危险因素的方法并不统一,突出了对基于证据的疾病特异性指南的需求。 

原始出处:

Isa F. Ashoor.et al.Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.012143

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    2019-07-11 zhaohui6731
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