Journal of Gastroenterology: 类固醇治疗自身免疫性胰腺炎期间糖尿病患者的胰岛素分泌可以改善

2019-09-18 不详 MedSci原创

自身免疫性胰腺炎(AIP)经常并发糖尿病(DM),但据报道,与AIP相关的DM在类固醇治疗后会有所改善。本研究的目的是根据DM的发病情况研究类固醇治疗期间的葡萄糖耐受不良改善情况。

背景
自身免疫胰腺炎(AIP)经常并发糖尿病(DM),但据报道,与AIP相关的DM在类固醇治疗后会有所改善。本研究的目的是根据DM的发病情况研究类固醇治疗期间的葡萄糖耐受不良改善情况。

方法
总共有61名接受AIP类固醇治疗的患者被纳入本研究。研究人员评估了C肽指数(CPI),胰岛素抵抗的稳态模型评估(HOMA-R),以及AIP诊断时和4周,1年和2年类固醇治疗后的胰腺直径。根据DM发病将患者分为三组:预先存在的DM(pDM),并发DM(cDM)和非DM(nDM)组。

结果
43名患者(71%)患有DM:15 pDM和28 cDM。在AIP诊断中,pDM(0.7,P = 0.007)和cDM(0.9,P = 0.018)患者的CPI低于nDM(1.3)。在类固醇治疗4周后,CPI在cDM(P <0.001)和nDM(P = 0.021)中有所改善。经过2年的类固醇治疗,HOMA-R增加(2.1-3.0,P = 0.007),但CPI逐渐改善(1.0-2.1,P = 0.004)。DM在23%的cDM中有所改善,而cDM中55%的胰岛素使用者停止使用胰岛素。

结论
AIP患者的DM与胰岛素分泌受损而非胰岛素抵抗相关。在并发DM患者的AIP类固醇治疗期间,胰岛素分泌可以报得到改善。

原始出处:

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    2019-11-13 许安
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    2020-07-17 gwc392
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  5. 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  6. 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content=<a href='/topic/show?id=6162838e390' target=_blank style='color:#2F92EE;'>#胰岛素分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83873, encryptionId=6162838e390, topicName=胰岛素分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Fri Sep 20 08:25:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474814, encodeId=efa214e48145c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Sep 20 08:25:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504782, encodeId=fe241504e82c0, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Sep 20 08:25:00 CST 2019, time=2019-09-20, status=1, ipAttribution=)]
    2019-11-07 baoya
  7. 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