Materials:新型生物活性玻璃为骨缺损患者带来新的治疗希望

2020-11-08 MedSci原创 MedSci原创

掺有治疗性金属离子的生物活性玻璃颗粒填充的可生物降解聚合物支架是一种修复临界尺寸骨缺损的新型和有前途的策略。

掺有治疗性金属离子的生物活性玻璃颗粒填充的可生物降解聚合物支架是一种修复临界尺寸骨缺损的新型和有前途的策略。

在这项研究中,研究人员通过冷冻干燥和盐浸法生产了基于聚(D,L-乳酸)(PDLLA)基质的支架,其中未掺杂和掺杂Cu-、Zn-和CuZn的生物活性玻璃颗粒。评价了玻璃颗粒的掺杂量和含量(10和30 wt.%)对支架的形态、压缩性能、磷灰石形成和降解行为的影响。

 

结果显示,支架呈现出高孔隙率(~93%),孔隙范围在100~400μm之间,由较小的孔隙相互连接,玻璃颗粒加入后,这种孔隙率得以保持。玻璃颗粒增强了聚合物支架,其弹性模量的改善幅度高达130%,并进一步促进了支架表面磷灰石的形成,这两种性能都取决于填料的数量和类型。生物活性玻璃颗粒促进了支架的降解,其中PDLLA/未掺杂的玻璃支架的降解率最高,但仍保持结构和尺寸的完整性。

综上所述,该结果表明,未掺杂和掺杂金属的生物活性玻璃的加入增加了支架的机械强度,促进了支架的生物活性,并改变了所得到的聚合物/玻璃支架的降解曲线,使其成为骨修复的更好候选者。

 

原始出处:

 

Julian Bejarano, Aldo R Boccaccini, et al., Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds. Materials (Basel). 2020 Jun 29;13(13):2908.  doi: 10.3390/ma13132908.

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    2020-11-10 lfcmxl
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    2020-11-10 182201837cm

    学习

    0

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    2020-11-09 Ash.L

    学习了

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