J Periodontol:慢性牙周炎牙龈内的分子标记物:一项基因组和蛋白质组学的分析

2019-01-21 lishiting MedSci原创

这项研究的目的是通过整个基因组转录和蛋白质谱的组学分析评估罹患牙周炎(CP)牙龈组织样本的分子标记物。

这项研究的目的是通过整个基因组转录和蛋白质谱的组学分析评估罹患牙周炎(CP)牙龈组织样本的分子标记物。研究通过基因表达microarray检测18名CP患者和25名对照牙龈组织的基因表达模式,通过LC-MS/MS对样本中提取的蛋白进行蛋白质组学的分析和比较。将转录和蛋白质组学中获取的数据进行整合并分析共有的基因和蛋白。结果显示,与对照组相比,CP中主要上调的基因为MZB1, BMS1P20, IGLL1/IGLL5, TNFRSF17, ALDH1A1, KIAA0125, MMP7, PRL, MGC16025, ADAM11,CP蛋白表达主要上调的为BPI, ITGAM, CAP37, PCM1, MMP-9, MZB1, UGTT1, PLG, RAB1B, HSP90B1。所能识别的基因功能包括:细胞死亡/存活、DNA复制、重组/修复、基因表达、生物发育、细胞间信号/相互作用、细胞发育、细胞生长/增殖、细胞聚集/结构、细胞功能/维护、细胞移动、B细胞发育。可识别的蛋白涉及到蛋白质折叠、压力反应、单有机体分解过程、肽酶活性的调控和细胞死亡的负面调控。对转录组学和蛋白组学的整合和验

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    2019-04-12 feather89
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    2019-11-17 wjywjy
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    2019-01-22 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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