Sci Rep:Bretschneider溶液诱导心脏手术患者的尿液代谢组改变

2018-12-17 xiangting MedSci原创

这项研究提供了确凿证据表明,HTK溶液在几种代谢途径引起明显的紊乱。

Bretschneider组氨酸-色氨酸-酮戊二酸(HTK)心脏停搏液的出现代表着心脏手术的重大进步,该停搏液具有显著的心肌保护作用。然而,这种添加物在全身引起的代谢变化尚未得到系统研究。这项研究使用基于非靶向质谱法深入探索尿液代谢组,试图整体和系统地描述HTK患者的代谢紊乱。

从100名接受过心脏手术的患者中前瞻性收集尿液样本,并使用高效化学同位素标记液相色谱-质谱法(LC-MS)对代谢组学变化进行分析。使用靶向来自尿液样品胺/酚代谢物的差异13C-/12C-丹酰标记LC-MS,对14,642个峰对或代谢物进行定量。

共确定了223种代谢物有显著的浓度变化(倍数变化>5),并聚集了几种来自这些失调代谢物的潜在代谢途径图。研究数据表明接受HTK的患者中,组氨酸代谢上调,随后伴谷氨酰胺/谷氨酸代谢增加、嘌呤和嘧啶代谢改变、维生素B6代谢增强。

这项研究提供了确凿证据表明,HTK溶液在几种代谢途径引起明显的紊乱,并为进一步研究HTK的器官保护或潜在害处的关键机制奠定了基础。

原始出处:

Cheng-Chia Lee. Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patients. Sci Rep. 11 December 2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1913897, encodeId=180b191389e7e, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Mon Aug 26 18:42:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449364, encodeId=f2c5144936417, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480295, encodeId=296e14802958f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050707, encodeId=37fc1050e079d, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Dec 17 14:42:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
    2019-08-26 ysjykql
  2. [GetPortalCommentsPageByObjectIdResponse(id=1913897, encodeId=180b191389e7e, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Mon Aug 26 18:42:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449364, encodeId=f2c5144936417, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480295, encodeId=296e14802958f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050707, encodeId=37fc1050e079d, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Dec 17 14:42:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1913897, encodeId=180b191389e7e, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Mon Aug 26 18:42:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449364, encodeId=f2c5144936417, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480295, encodeId=296e14802958f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050707, encodeId=37fc1050e079d, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Dec 17 14:42:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1913897, encodeId=180b191389e7e, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Mon Aug 26 18:42:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449364, encodeId=f2c5144936417, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480295, encodeId=296e14802958f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Wed Dec 19 02:42:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050707, encodeId=37fc1050e079d, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Dec 17 14:42:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
    2018-12-17 明天jing

    代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。

    0

相关资讯

JAHA:心脏手术前要不要停用ACEI/ARB?

由此可见,这项评估心脏手术前常规继续服用或停用ACEI或ARB的随机研究是可行的,并且治疗分配与术后生理或临床结局的差异无关。

The Heart Surgery Forum:心脏手术可在患者自身温度下进行无需主动降温

虽然低温常用于心脏手术,但它有不良影响。我们相信心脏手术可以安全地在患者自身的温度下进行,无需主动降温以避免这些不良影响。

Heart:低危儿童心脏手术中常温与低温体外循环的比较

常温CPB与低温CPB一样安全有效,可作为灌注策略常规用于接受心脏直视手术的低危婴童。

Paediatric Anaesthesia:预防性使用右美托咪定预防小儿心脏手术后交界性异位性心动过速的疗效

预防性使用右美托咪定可明显降低先天性心脏手术儿童术后异位心动过速的发生率,并且无明显副作用。

JAHA:步行速度和心脏手术后的1年死亡率

步速是一种简单的工具,可用于筛查虚弱患者,并识别在术后早中期有不良事件风险的老年人。

2018 国际共识声明:心脏手术患者直接口服抗凝药物围术期管理

尽管目前针对染中围术期出血的管理有了指南建议,但关于心脏外科手术患者直接口服抗凝药物的围术期监测和管理还没有适用性指导。本文主要针对这些内容提出指导建议。