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Diabetes Care：成纤维细胞生长因子23与正常或轻度肾功能受损的2型糖尿病患者死亡率

2019-09-09 xing.T MedSci原创

成纤维细胞生长因子23正常或轻度肾功能受损2型糖尿病死亡率
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由此可见，对于肾功能正常或轻度受损的2型糖尿病患者，FGF23与心血管事件和死亡风险增加有关。

近日，糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章，研究人员旨在探究成纤维细胞生长因子23（FGF23）是否与肾功能正常或轻度受损的2型糖尿病患者不良预后相关。

研究人员测量了310例2型糖尿病患者的FGF23水平，这些患者估计的肾小球过滤速率≥60mL/min/1.73m2。研究人员通过Cox回归分析了FGF23与全因死亡率和主要不良心血管事件（MACE）之间的相关性。

在随访5.8年（3.3-6.5）期间，47名患者发生MACE，28名患者死亡。FGF23与全因死亡（年龄和性别调整风险比为2.78 [95％CI为1.76-4.40]）和MACE（1.67 [1.12-2.49]）风险增加相关。在对其他潜在混杂因素进行额外调整后，结果相似，并且在独立队列中可重复出一致的结果。

由此可见，对于肾功能正常或轻度受损的2型糖尿病患者，FGF23与心血管事件和死亡风险增加有关。 

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    2020-05-24 yese

    #肾功能#

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    2019-12-25 ms5439512287675881

    #BET#

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    2020-06-22 ms9608593228839890

    #DIA#

    0

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createdBy=6c516518840, createdName=marongnuan, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474809, encodeId=b9eb14e4809fa, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=)]
    2020-03-10 sunylz

    #患者死亡#

    0

  5. 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createdBy=6c516518840, createdName=marongnuan, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474809, encodeId=b9eb14e4809fa, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=)]
    2019-09-13 木头人513

    #Diabetes#

    0

  6. 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createdBy=6c516518840, createdName=marongnuan, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474809, encodeId=b9eb14e4809fa, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=)]
    2019-11-01 ms5906905816781247

    #成纤维细胞生长因子23#

    0

  7. 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    2019-09-10 zhishijing

    #成纤维细胞#

    0

  8. 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createdBy=6c516518840, createdName=marongnuan, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474809, encodeId=b9eb14e4809fa, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=)]
    2019-09-10 aids213

    #2型糖尿病患者#

    0

  9. 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createdBy=6c516518840, createdName=marongnuan, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474809, encodeId=b9eb14e4809fa, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Sep 10 22:32:00 CST 2019, time=2019-09-10, status=1, ipAttribution=)]
    2019-09-10 marongnuan

    #纤维细胞#

    0

  10. 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    2019-09-10 xue8604

    #糖尿病患者#

    0

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JCEM：1岁幼儿体内的成纤维细胞生长因子23（FGF23）浓度受哪些因素调控？

背景：磷是人体内最丰富的元素之一，体内磷的多以磷酸盐（PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L)，婴儿PO4要高50%，儿童高30%，大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23（FGF23）在磷酸盐代谢中起着重要的作用，但目前的研究不能充分解释它的调节特征。目的：本研究探讨了在儿童早期时FGF23受哪些因素调控，特别是性别和铁