Eur J Cancer:90%以上的皮肤黑色素瘤可归因于太阳紫外线照射?!!

2021-11-09 Nebula MedSci原创

请注意防晒!90%以上的皮肤黑色素瘤都可归因于太阳紫外线辐射暴露

在过去的50年里,皮肤黑色素瘤(CM)在白种人中的发病率升高很大程度上可归因于太阳紫外线辐射(UVR)暴露的增加(通常表示为人口归因比[PAF])。因此,可以通过减少太阳紫外线辐射暴露来预防许多皮肤黑色素瘤。

本研究旨在估计1943年至2036年期间丹麦和德国萨尔因太阳紫外线辐射暴露和人口变化引起的皮肤黑色素瘤的人口归因比。

研究人员从 NORDCAN 数据库和萨尔癌症登记处检索丹麦(1943-2016年)和德国萨尔州联邦(1972-2016年)的皮肤黑色素瘤发病率数据(ICD-10,C43)。通过将1943年至1946年期间丹麦的皮肤黑色素瘤发病率与当代或预测的皮肤黑色素瘤发病率进行比较,计算出可归因于太阳紫外线辐射暴露的皮肤黑色素瘤数量。

丹麦可归因于太阳紫外线辐射暴露的皮肤黑色素瘤的病例变化

在丹麦,可归因于太阳紫外线辐射暴露的皮肤黑色素瘤的病例比例从1947-1951年的20%左右升高到了2012-2016年的96%;在德国萨尔州联邦,可归因于太阳紫外线辐射暴露的皮肤黑色素瘤的病例比例从1972-1976年的50%升高到了2012-2016年的90%。到2032-2036年,丹麦和萨尔州联邦的人口归因比预计分别会升高到97%和92%。此外,人口因素对皮肤黑色素瘤的发病率的影响相当小。

德国可归因于太阳紫外线辐射暴露的皮肤黑色素瘤的病例变化

综上所述,德国和丹麦90%以上的皮肤黑色素瘤都可归因于太阳紫外线辐射暴露,因此,可通过减少太阳紫外线辐射暴露来预防皮肤黑色素瘤的发生。该研究结果强调了一级预防策略的需求,有助于引发人们对皮肤黑色素瘤及其风险因素的重视,从而通过改变日常生活习惯来减少太阳紫外线辐射暴露。

原始出处:

Keim Ulrike,Gandini Sara,Amaral Teresa et al. Cutaneous melanoma attributable to UVR exposure in Denmark and Germany.[J] .Eur J Cancer, 2021, 159: 98-104. https://doi.org/10.1016/j.ejca.2021.09.044

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    2022-02-15 sunylz
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